Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review

Hojo, Mariko; Miwa, Hiroto; Yokoyama, Tetsuji; Ohkusa, Toshifumi; Nagahara, Akihito; Kawabe, Masato; Asaoka, Daisuke; Izumi, Yuko; Sato, Nobuhiro

doi:10.1007/s00535-005-1687-8

Cited by 99 publications

(58 citation statements)

References 32 publications

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“…Antidepressive drugs seem to be helpful in the treatment in some cases of FD patients (Mertz et al, 1998;Otaka et al, 2005). A meta-analysis published in 2005 demonstrated that anti-anxiety or anti-depressive drugs were effective in controlling symptoms in patients with FD (Hojo et al, 2005). However, some serotonin selective reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors were not more effective than placebo (van Kerkhoven et al, 2008;Tan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Piriyapong

Tangaroonsanti²,

Mahachai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection Impacts on Functional Dyspepsia in Thailand

Piriyapong

Tangaroonsanti²,

Mahachai³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…In Japan, an RCT was done on the efficacy of tandospirone citrate (a 5-HT1A agonist) in improving symptoms of patients with FD [63]. In addition, two meta-analyses have shown the efficacy of antidepressants and anxiolytics in the treatment of FD patients [64,65]. However, as of this writing only a few reports describe large-scale randomized clinical trials using these psychiatric drugs for FD.…”

Section: Treatmentmentioning

confidence: 99%

Evidence-based clinical practice guidelines for functional dyspepsia

et al. 2015

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General interest in functional gastrointestinal disorders is increasing among Japanese doctors as well as patients. This increase can be attributed to a number of factors, including recent increased interest in quality of life and advances in our understanding of the pathophysiology of gastrointestinal disease. Japan recently became the world's first country to list ''functional dyspepsia'' as a disease name for national insurance billing purposes. However, recognition and understanding of functional dyspepsia (FD) remain poor, and no standard treatment strategy has yet been established. Accordingly, the Japanese Society of Gastroenterology (JSGE) developed an evidence-based clinical practice guideline for FD, consisting of five sections: concept, definition, and epidemiology; pathophysiology; diagnosis; treatment; and prognosis and complications. This article summarizes the Japanese guideline, with particular focus on the treatment section. Once a patient is diagnosed with FD, the doctor should carefully explain the pathophysiology and benign nature of this condition, establish a good doctor-patient relationship, and then provide advice for daily living (diet and lifestyle modifications, explanations, and reassurance). The proposed pharmacological treatment is divided into two steps: initial treatment including an acid inhibitory drug (H2RA or PPI) or prokinetics, (strong recommendation); second-line treatment including anxiolytics, antidepressants, and Japanese traditional medicine (weak recommendation). H. pylori eradication, strongly recommended with a high evidence level, is positioned separately from other treatment flows. Conditions that do not respond to these treatment regimens are regarded as refractory FD. Patients will be further examined for other organic disorders or will be referred to specialists using other approaches such as psychosomatic treatment.

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“…It involves many pathogenic factors and different pathophysiological disturbances, including delayed gastric emptying, impaired accommodation, and hypersensitivity to gastric distention. Treatment of the underlying pathophysiological abnormality seems logical, but the main pharmacotherapeutic options include acid suppression, prokinetic drugs, and antidepressants [6,[24][25][26], all of which have limited effects. Herbal formulations are widely used to treat FD in China and many other areas in the world.…”

Section: Discussionmentioning

confidence: 99%