Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial

Zhao, Liang; Zhang, S. S.; Wang, Z. F.; Wiebrecht, Axel

doi:10.1016/j.dza.2013.11.009

Cited by 18 publications

(22 citation statements)

References 19 publications

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“…TCM has been used for many years to improve life quality by effectively reducing the cisplatin-induced side effects including nephrotoxicity and myelosuppression. 2,6,11,13,18,20,24,[28][29][30][31][32][33][34][35][36][37] There have been no reports of the effect of HWKL on cisplatin-induced nephrotoxicity and myelosuppression despite there being many studies on BXXXT. The herbs involved in HWKL are considered to help improve stomach, kidney and spleen functions due to its properties.…”

Section: Discussionmentioning

confidence: 99%

“…Although a lot of research has been carried out on BXXXT, there have been few studies into the properties and possible mechanism of action of BXXXT. 17,18,20 Furthermore, there have been no studies of the pharmacological effects of HWKL on cisplatin-induced nephrotoxicity and myelosuppression. Our present work described here aimed to investigate the protective effects and possible mechanisms of action of HWKL on cisplatin-induced nephrotoxicity and myelosuppression.…”

Section: Introductionmentioning

confidence: 99%

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He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

et al. 2017

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“…Traditional Chinese Medicine (TCM) is an effective alternative treatment for FD [8][9][10][11][12][13][14][15][16]. According to TCM, FD is divided into different syndromes based on the clinical symptoms and signs, among which "spleen-deficiency and qi-stagnation" is the most common one [17].…”

Section: Introductionmentioning

confidence: 99%

Sini‐San Regulates the NO‐cGMP‐PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The present study investigated the effect of Chinese medicine Sini-San (SNS) on visceral hypersensitivity in a rat model of functional dyspepsia (FD), and it explored related underlying mechanisms. The rat model of FD was developed by combining neonatal iodoacetamide (IA) treatment and adult tail-clamping. After SNS treatment, the behavior and electromyographic testing were performed to evaluate the visceromotor responses of rats to gastric distention. Immunofluorescence was used to detect the distribution of iNOS-positive cells in the spinal dorsal horn, while the real-time quantitative PCR and western blot were used for detection of the gene expression of c-fos, iNOS, and GABAb and protein levels of iNOS and GABAb in the spinal dorsal horn, respectively. The protein concentration of cGMP and PKG proteins in the spinal dorsal horn were quantified by enzyme-linked immunosorbent assay. In this study, SNS treatment significantly reduced the behavioral score and electromyographic response to graded intragastric distension pressure. The middle-dose of SNS treatment significantly reduced the distribution of iNOS-positive cells in the spinal dorsal horn of FD model rats. The gene expression of c-fos, iNOS, and GABAb and the protein contents of iNOS, GABAb, cGMP, and PKG in the spinal dorsal horn of FD model rats were restored to a normal level by middle-dose of SNS treatment. Our results suggest that Sini-San may alleviate the visceral hypersensitivity in FD model rats via regulation of the NO/cGMP/PKG pathway in the spinal dorsal horn.

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“…The literature search yielded 1818 citations, of which 1651 were excluded because they were not clinical trials or written in English. Of the 167 therapeutic trials, 109 did not match the inclusion criteria, leaving 58 studies for the present review . During the time period examined, most of the studies adopted the Rome II criteria (59%), whereas Rome I and Rome III were selected for inclusion criteria in 10% and 31% of the clinical trials respectively.…”

Section: Resultsmentioning

confidence: 99%

Review article: adherence to Rome criteria in therapeutic trials in functional dyspepsia

Stanghellini

Cogliandro

2014

Aliment Pharmacol Ther

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Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial

Cited by 18 publications

References 19 publications

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis

Sini‐San Regulates the NO‐cGMP‐PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

Review article: adherence to Rome criteria in therapeutic trials in functional dyspepsia

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