Treatment of chronic ulcers with chlorophyll

Chlorophylls and their Derivatives Used in Food Industry and Medicine

“…The same wound healing properties of Chl derivatives were also reported from several early human case reports using either chlorophyllin solutions (with different Na-chlorophyllins, Na-Fe-chlorophyllin, Na-Cu-chlorophyllin, the Mgcontaining form being the less irritating to the mucosal membranes in otorhinolaryngology) or ointments and suppositories containing chlorophyllin, Chl a or Chl b [209,315,318,320,322]. There are reports about the application of Chl and derivatives in various suppurative and acute diseases, oral sepsis and/or infections, chronic ulcer and other ulcers [209,[318][319][320]322], and post-operative wounds from rectal surgery [315]. However, it has to be noted that other reports found no positive wound healing property of chlorophyllin in the treatment of human burns, surgical infections and ulcers [333].…”

“…Obviously, these compounds were more effective in wound healing or in the treatment of suppurative diseases when combined with antibacterial and/or other agents (e.g., penicillin and/or papain/urea) [315,316,319,334]. inhibition of hyaluronidase activity in vitro [310] Chlorophyllin decreased body, fecal and urinary odor, eased constipation and flatus in geriatric, ileostomy and colostomy patients [208,311] treatment of trimethylaminuria in humans [312] decreased deposition of calcium oxalate crystals in rat kidney induced by hydroxy-L-proline, ethylene glycol or Na-oxalate treatment in vivo [313,314] mild bacteriostatic effect on some bacteria [209,315] accelerated healing of experimentally induced clean or infected wounds or lesions (infected with Staphylococcus pyogenes or Streptococcus hemolyticus), and in different burns in guinea pigs, rats, rabbits and dogs in vivo [316,317] and references therein healing of suppurative diseases, various post-operative surgical infections, diverse lesions, open wounds, empyema, streptococcic septicemia, bacterial endocarditis, osteomyelitis, ulcers in humans [209,[318][319][320] treatment of rhinitis, rhinosinusitis, chronic otitis in humans [209] treatment of oral infections, gingival inflammation, Vincent's stomatitis, pyorrhea in humans [209,321,322] treatment of acute and chronic rectal infections and wound healing in proctology in humans [315] treatment of mild-moderate photodamage and solar lentigines in a human pilot study [323] treatment of mild-moderate facial acne and large visible pores in a human pilot study [324] treatment of facial redness, rosacea in human case studies [325] immunostimulatory effect, inhibition of homeostasis driven proliferation in CD4+ T cells in vitro, and in lymphopenic mice in vivo [326] immunomodulatory and immunosuppressive effect on lipopolysaccharidestimulated murine splenic mononuclear cells in vitro [327] anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 murine m...…”

Chlorophyll Extraction from Microalgae: A Review on the Process Engineering Aspects

“…Chronic ulcer is a significant health problem in society, with lengthy periods required for its treatment [13]. Chlorophyll's ability to increase the rate of healing is a breakthrough for ulcer sufferers.…”

“…Chlorophyll's ability to increase the rate of healing is a breakthrough for ulcer sufferers. The application of ointments containing chlorophyll derivatives was found not only to eliminate pain after several days but also to improve the appearance of the affected tissues [13]. The discharge from the ulcer and its characteristic odour also improved significantly after a few days of chlorophyll treatment [13].…”

Low light intensity and nitrogen starvation modulate the chlorophyll content of Scenedesmus dimorphus

“…Chlorophyll is a vital active photosynthetic natural pigment widely distributed in plants and algal organisms (Humphrey ). In addition to its biological importance, chlorophyll has great potential as a biotechnological product, where it is already used as natural food colouring (Timberlake and Henry ) and has health benefits in the fields of cosmetology, making part of products such as shampoos, deodorants and facial and body moisturizers (Ahad ), and dermatology, due to its effectiveness in dermatitis treatment (Cady and Morgan ). Chlorophyll and its derivatives have been studied as physiologically active components of the human diet.…”