Treatment of Atherogenic Liver Based on the Pathogenesis of Nonalcoholic Fatty Liver Disease: A Novel Approach to Reduce Cardiovascular Risk?

Maurantonio, Mauro; Ballestri, Stefano; Odoardi, Maria Rosaria; Lonardo, Amedeo; Loria, Paola

doi:10.1016/j.arcmed.2011.08.004

Cited by 36 publications

(31 citation statements)

References 262 publications

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“…In the meantime, from the perspective of clinical practice, the notion that NAFLD is a powerful trigger and amplifier of adverse CVD outcomes can justify targeting NAFLD in the attempt to reduce the risk of incident CVD (as schematically summarized in Figure 3) [2][3][4][5]66,91,[144][145][146][147][148].…”

Section: Discussionmentioning

confidence: 99%

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Non-alcoholic fatty liver disease and risk of cardiovascular disease

et al. 2016

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Section: Discussionmentioning

confidence: 99%

“…Based on data presented in this manuscript and on further published evidence [2][3][4][5]91,[143][144][145][146][147], this cartoon summarizes how lifestyle and drug interventions might mechanistically reduce CVD risk by targeting various aspects of NAFLD pathogenesis and histology. …”

Section: Subcellular Localizationmentioning

confidence: 95%

Non-alcoholic fatty liver disease and risk of cardiovascular disease

et al. 2016

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“…Conversely, an increase in triglycerides remained significantly associated with an increased prevalence of fatty liver after multi-variable adjustment. This is not surprising, as the pathogenesis of fatty liver is characterized by an imbalance between the rate of hepatic triglyceride synthesis and removal (32). …”

Section: Discussionmentioning

confidence: 99%

Ethnic and Sex Differences in Fatty Liver on Cardiac Computed Tomography: The Multi-Ethnic Study of Atherosclerosis

Tota-Maharaj

Blaha²,

Zeb

et al. 2014

Mayo Clinic Proceedings

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Objective To describe ethnic and gender differences in the prevalence and determinants of fatty liver in a multi-ethnic cohort. Patients and Methods We studied participants from the Multi-Ethnic Study of Atherosclerosis who underwent baseline non-contrast cardiac CT between July 2000-August 2002, and had adequate hepatic and splenic imaging for fatty liver determination (n=4088). Fatty liver was diagnosed by a liver/spleen attenuation ratio <1. We compared the prevalence and severity of fatty liver, among four ethnicities (White, Chinese, African American, Hispanic), stratifying by obesity and metabolic syndrome. Multivariable ordinal logistic regression was employed to determine the impact of cardio-metabolic risk factors on fatty liver prevalence in different ethnicities. Results The prevalence of fatty liver varied significantly by ethnicity (White 15%, Chinese 20%, African-American 11%, Hispanic 27%, p<0.001). Although African-Americans had the highest prevalence of obesity, a smaller percentage of obese African Americans were diagnosed with fatty liver compared to other ethnicities (African American 17%, White 31%, Chinese 37%, Hispanic 39%, p<0.001). Hispanics demonstrated the highest prevalence of fatty liver, including among the obese and metabolic syndrome population. An increase in insulin resistance predicted a two-fold increased prevalence of fatty liver in all ethnicities after multi-variable adjustment. Conclusion African-Americans have a lower prevalence, and Hispanic Americans a higher prevalence of fatty liver compared to other ethnicities. There are distinct ethnic variations in the prevalence of fatty liver even among patients with the metabolic syndrome or obesity, suggesting that genetic factors may play a significant role in the phenotypic expression of fatty liver.

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“…Indeed, those people with NAFLD have been reported to have an increased risk for CVD as assessed by a variety of outcomes such as coronary artery calcium scoring [4,6], coronary angiography [8,9], endothelium-dependent flow mediated dilation [10], left ventricular mass index [11] and carotid intima media thickness (IMT) [12]. In addition, those with NAFLD have a two-fold risk of CVD mortality, independent of the MetS and other established CVD risk factors [13]. As the majority of these studies have been limited to high risk individuals with features of the MetS, it is not clear if these results are applicable to healthy or low risk populations.…”

Section: Introductionmentioning

confidence: 99%