Non-alcoholic fatty liver disease and risk of cardiovascular disease

Cardiovascular Disease, Cancer, and Mortality Among People With Type 2 Diabetes and Alcoholic or Nonalcoholic Fatty Liver Disease Hospital Admission

“…The absolute risks of the outcomes of interest in this sub-group of people who, in general, have less severe liver disease are expected to be intermediate between people without liver disease and people with severe liver disease who are likely to form the majority of our population of people with a record of hospital admission with liver disease (11,12). Consequently, we expect that the relative risks describing the association between severe liver disease and outcomes of interest would be larger than we have reported if we had been able to exclude people with liver disease from the comparison group.…”

Non-alcoholic fatty liver disease with and without metabolic syndrome: Different long-term outcomes

“…The prevalence of NAFLD is approximately 20-30% in developed societies, but reaches up to 70-90% among subjects with obesity or diabetes [7]. The evidence that NAFLD is an independent risk factor for cardiovascular diseases [7][8][9] as well as for T2D [10][11][12] is solid. Moreover, the presence of both NAFLD and T2D…”

The Relationship Between the Prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) with the Severity of Coronary Artery Disease (CAD) in Patients Undergoing Coronary Artery Angiography: A Cross- Sectional Study

“…Nonalcoholic steatohepatitis may lead to fibrosis, cirrhosis, and liver failure. NAFLD is associated with visceral obesity, hypertension, dyslipidemia, insulin resistance, type 2 diabetes mellitus, and CAD (2)(3)(4)(5). All of these factors are defined as clinical features of metabolic syndrome (MetS).…”

“…There is an important clinical association between NAFLD and MetS components (6,7). However, emerging evidences suggest that the risk of CAD in NAFLD is independent of other metabolic risk factors and cardiovascular disease is the most important cause of death in patients suffering from NAFLD (3,8). Although the exact reason is not yet completely understood, increasing the activity of inflammatory mediators, decreasing the endothelial function, adiponectin levels, collateral circulation, vascular repair capacity, and atherogenic lipoprotein profile are mentioned as related factors of CAD in NAFLD patients (8, 9).…”