Treatment of alopecia areata with the 308‐nm xenon chloride excimer laser: Case report of two successful treatments with the excimer laser

Gundogan, C.; Greve, Bärbel; Raulin, PD Christian

doi:10.1002/lsm.20002

Cited by 56 publications

(44 citation statements)

References 24 publications

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“…With this device, UVB can be irradiated to only one or a few individual patches, with adequate protection of the surrounding healthy skin. So far, there have been only a few studies [7,[17][18][19][20] on the use of excimer light therapy in AA.…”

Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

“…The choice of initial dose in most of the studies that have used a light source as a therapeutic modality is determined by MED [7,[17][18][19][20]. We, however, did not follow the MED protocol and chose an initial dose of 300 mJ/cm 2 without determining MED in our patients.…”

Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

“…We, however, did not follow the MED protocol and chose an initial dose of 300 mJ/cm 2 without determining MED in our patients. The reason why we chose this approach was as follows: firstly it may not be easy to calculate MED in type IV and V skin, which is present in all our patients, and secondly, Gundogan et al [17] also used the initial dose of 300 mJ/cm 2 in an AA patient who had type 1 skin and 600 mJ/cm 2 in a patient with type III skin. In each patient, we irradiated only one half of the patch, and the other half covered with a black rubber shield served as a control.…”

Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

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Original papers A study on efficacy of 308 nm excimer light therapy in alopecia areata

Sanga¹,

Mittal²

2015

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Introduction. Alopecia areata (AA) is an autoimmune condition characterized by T-cell-mediated attack on hair follicles.Objective. Evaluation of efficacy of 308 nm excimer light in the treatment of alopecia areata. Material and methods.Patches of AA were treated twice weekly, but not on 2 consecutive days, with UVB excimer 308 nm light. In all patients, half of the AA patch was irradiated and the other half was spared, covered with a black rubber shield and taken as a control. Therapy was started with an initial dose of 300 mJ/cm 2 , with an incremental dose of 100 mJ/cm 2 at every sitting until fine erythema appeared.Results. At the end of the treatment, one patient (3.33%) at the test site showed > 50% hair regrowth vs. none at the control site. After a 2-month post-treatment period, successful hair regrowth (grades 3 and 4) was seen in 12 patients at test sites and in 2 patients at control sites. The differences were statistically significant (p < 0.05). After 4 months successful hair regrowth (grades 3 and 4) was seen in 16 patients at test sites and in 5 patients at control sites. The differences were statistically significant (p < 0.05). There was no statistically significant difference in the response to treatment in relation to the duration of the disease (p > 0.05). Conclusions.Excimer light has the potential to stimulate hair regrowth in patches of alopecia areata.streszczenie Wprowadzenie. Łysienie plackowate (alopecia areata -AA) jest chorobą autoimmunologiczną charakteryzującą się atakiem limfocytów T na mieszek włosowy. Cel pracy. Ocena skuteczności światła ekscymerowego w terapii pojedynczych ognisk AA. Materiał i metodyka.Ogniska AA naświetlano 2 razy w tygodniu (ale nie w kolejnych dniach) promieniowaniem ekscymerowym (UVB) o długości fali 308 nm. U wszystkich pacjentów napromieniowywano jedną połowę ogniska, natomiast druga, osłonięta czarną gumą, służyła jako kontrola. Naświetlania rozpoczynano od dawki 300 mJ/cm 2 , którą zwiększano o 100 mJ/cm 2 podczas kolejnych naświetlań aż do uzyskania wyraźnego rumienia.A study on efficacy of 308 nm excimer light therapy in alopecia areata badania nad skutecznością promieniowania ekscymerowego o długości fali 308 nm w leczeniu łysienia plackowatego zo nun sanga, Asit Mittal

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Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

Section: Rycina 7 Wyniki Leczenia W Zależności Od Czasu Trwania Chorobymentioning

confidence: 99%

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Original papers A study on efficacy of 308 nm excimer light therapy in alopecia areata

Sanga¹,

Mittal²

2015

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“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, the use of biologics and laser therapy in alopecia areata have shown some beneficial results. [21][22][23] There has been a recent spurt in application of platelet-rich plasma (PRP) in dermatology and aesthetic medicine. 24 Overall, PRP seems to be a promising therapeutic modality but the level of evidence as of now, from the available published data is low.…”

Section: Introductionmentioning

confidence: 99%

A clinical study on alopecia areata

Ninama¹,

Mahajan²,

Bilimoria³

et al. 2018

Int J Res Dermatol

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Background: Alopecia areata (AA) is a common auto-immune condition, causing hair loss. This disease has limited treatment modalities. Through this study, comparison between established modalities of treatment such as oral mini pulse therapy, intralesional corticosteroids and platelet-rich plasma (PRP) as a newer modality has been done. The objective of the study was to evaluate the efficacy and safety of various treatment modalities in alopecia areata.Methods: 45 patients with alopecia areata presenting to the OPD of Dermatology, Dhiraj hospital, Pipariya were included in this study. It was conducted as a randomized prospective study for a period of 16 weeks. After taking informed consent, patients were randomly distributed into three treatment groups. Group 1 patients were treated with Tab. Betamethasone 0.1 mg/kg every Saturday and Sunday, Group 2 was treated with Inj. Triamcinolone acetonide 10 mg/ml for scalp and 2.5 mg/ml for eye brows and face was injected into deep dermis; Group 3 was treated with Dermaroller followed by application of activated platelet rich plasma (PRP). SALT score was calculated at first visit and 16 weeks. Regrowth was calculated using Mac Donald and Null Horis grading Scale at 16 weeks.Results: The SALT score reduced from 13.27 to 7.52 in Group 1, 13.93 to 8.16 in Group 2 and 42.32 to 21.12 in Group 3. Mean grade of regrowth of hairs observed was 3.47, 3.80, 2.93 in Group 1, 2, 3 respectively. The results were analysed using paired t test.Conclusions:Intralesional corticosteroids viz. triamcinolone acetonide still remains the first choice of therapy for AA in adults with limited involvement. Systemic corticosteroids give lower response than intralesional steroids. Platelet Rich Plasma (PRP) showed promising results, especially in children and in extensive involvement. Compared to other treatment modalities Inj. PRP is safe and with less side effects.

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“…16 With the discovery of AA as an autoimmune disorder with T cell-mediated inflammation of the hair follicle, 15 the use of excimer lasers has been suggested. Since the benefit of the excimer laser on AA first reported by Gundogan et al, 20 numerous studies have confirmed its efficacy. [21][22][23] The largest study so far was done on 18 patients with recalcitrant AA that involved the scalp, beard, arms and legs.…”

Section: -Nm Excimer Lasermentioning

confidence: 93%

Use of Lasers in the Treatment of Alopecia Areata

Chu

Kim

2016

Medical Lasers

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Alopecia areata (AA) is a complex autoimmune disease characterized by round or oval patches of non-scarring hair loss that is mediated by lymphocytes affecting the hair follicles. To treat localized AA, intralesional corticosteroid injections and topical corticosteroids are most commonly used, while for widespread AA, systemic steroids, immunosuppresants, and contact immunotherapy are commonly considered. However, therapeutic options for refractory AA that is unresponsive to these conventional treatments are limited. Various lasers have been suggested in recent studies to treat AA. The effect of 308-nm excimer laser was the most studied, while others, including neodymium-doped yttrium aluminum garnet, erbium:glass laser, fractional CO2 laser, and low-level laser therapy, have also been assessed. Despite the nascent state of research on lasers as a treatment option for AA, there have been a great deal of promising results. It is possible for lasers to become the mainstay treatment option of AA. Key words

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Treatment of alopecia areata with the 308‐nm xenon chloride excimer laser: Case report of two successful treatments with the excimer laser

Cited by 56 publications

References 24 publications

Original papers A study on efficacy of 308 nm excimer light therapy in alopecia areata

Original papers A study on efficacy of 308 nm excimer light therapy in alopecia areata

A clinical study on alopecia areata

Use of Lasers in the Treatment of Alopecia Areata

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