A clinical study on alopecia areata

Abstract

<p class="abstract"><strong>Background:</strong> Alopecia areata (AA) is a common auto-immune condition, causing hair loss. This disease has limited treatment modalities. Through this study, comparison between established modalities of treatment such as oral mini pulse therapy, intralesional corticosteroids and platelet-rich plasma (PRP) as a newer modality has been done. The objective of the study was to evaluate the efficacy and safety of various treatment modalities in alopecia areata.</p><p class="abstract"><strong>Methods:</strong> 45 patients with alopecia areata presenting to the OPD of Dermatology, Dhiraj hospital, Pipariya were included in this study. It was conducted as a randomized prospective study for a period of 16 weeks. After taking informed consent, patients were randomly distributed into three treatment groups. Group 1 patients were treated with Tab. Betamethasone 0.1 mg/kg every Saturday and Sunday, Group 2 was treated with Inj. Triamcinolone acetonide 10 mg/ml for scalp and 2.5 mg/ml for eye brows and face was injected into deep dermis; Group 3 was treated with Dermaroller followed by application of activated platelet rich plasma (PRP). SALT score was calculated at first visit and 16 weeks. Regrowth was calculated using Mac Donald and Null Horis grading Scale at 16 weeks.<strong></strong></p><p class="abstract"><strong>Results:</strong> The SALT score reduced from 13.27 to 7.52 in Group 1, 13.93 to 8.16 in Group 2 and 42.32 to 21.12 in Group 3. Mean grade of regrowth of hairs observed was 3.47, 3.80, 2.93 in Group 1, 2, 3 respectively. The results were analysed using paired t test.</p><strong>Conclusions:</strong>Intralesional corticosteroids viz. triamcinolone acetonide still remains the first choice of therapy for AA in adults with limited involvement. Systemic corticosteroids give lower response than intralesional steroids. Platelet Rich Plasma (PRP) showed promising results, especially in children and in extensive involvement. Compared to other treatment modalities Inj. PRP is safe and with less side effects.<p> </p>

Intralesional triamcinolone acetonide versus platelet rich plasma: a comparative study in the treatment of alopecia areata of scalp

“…23 The mean grading score of 3.57 is significantly higher in group I patches as compared to group II (2.63) at fourth follow-up. 24 Another Indian study by Agrawal et al also reported the response of intralesional triamcinolone acetonide (33.3%) for the treatment of scalp AA to be better than with intralesional PRP therapy (3.33%). 25 In a study by Shumez et al, PRP had an earlier response at the end of 6 weeks as compared to triamcinolone; however, this difference was statistically insignificant which is opposite to index study result.…”

Low Level Laser versus Platelet-rich Plasma in Treatment of Alopecia Areata: A Randomized Controlled Intra-patient Comparative Study

“…These GFs are believed to stimulate stem cells sited in HF at the bulge areas leading to growth of fresh follicles and enhancing angiogenesis [13], [15]. Despite of its promising results in AA, a paucity of randomized controlled clinical trials had been published to assess the efficiency of PRP in management of AA [9], [13], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], 29], [30], [31], [32], [33], [34], [35]. Photobiomodulation (PBM), or low-level laser (or) light therapy (LLLT) is using red light (600-700 nm) or near infrared (700 nm-1000+nm) which is obtained from 5 to 500 mW light-emitting diode (LED) source [36], [37].…”

Study the Effect of Ipomea carnea Jacq. Patra swarasa (Leaves Juice) in Treatment of Indralupta (Alopecia Areata): A Pilot Study

“…It symptomatically can be correlated to Alopecia Areata [2]. Alopecia Areata is hypothesized to be an organ specific autoimmune disease mediated by T lymphocytes directed to the hair follicles and of unknown aetiology [3].…”

“…Ipomoea carnia jacq, belongs to convolvulaceae family found everywhere in India which is native of tropical America [9] and the main character of the plant is that it can regenerate very fast from its part in dry as well as the moist surfaces. Due to this unique character this plant is locally termed as thethar or besharam.…”

“…Indralupta treated with Jalukavcharana [17],Mittal Shivani et al used jaypal beeja lepa and Jalukavcharana to treat Indralupta [18],Rahul Shingadiya et al successfully treated a case of Indralupta with Gunja beeja lepa, Gunja oil and other oral medicines[19]. Kishan Ninama et al has done clinical study on alopecia areata with Systemic corticosteroids, intralesional corticosteroids and intralesional platelet rich plasma where intralesional corticosteroids considered the first line of treatment[20][21][22][23][24].…”