Original papers A study on efficacy of 308 nm excimer light therapy in alopecia areata

Abstract

Introduction. Alopecia areata (AA) is an autoimmune condition characterized by T-cell-mediated attack on hair follicles.Objective. Evaluation of efficacy of 308 nm excimer light in the treatment of alopecia areata. Material and methods.Patches of AA were treated twice weekly, but not on 2 consecutive days, with UVB excimer 308 nm light. In all patients, half of the AA patch was irradiated and the other half was spared, covered with a black rubber shield and taken as a control. Therapy was started with an initial dose of 300 mJ/cm 2 , with an incremental dose of 100 mJ/cm 2 at every sitting until fine erythema appeared.Results. At the end of the treatment, one patient (3.33%) at the test site showed > 50% hair regrowth vs. none at the control site. After a 2-month post-treatment period, successful hair regrowth (grades 3 and 4) was seen in 12 patients at test sites and in 2 patients at control sites. The differences were statistically significant (p < 0.05). After 4 months successful hair regrowth (grades 3 and 4) was seen in 16 patients at test sites and in 5 patients at control sites. The differences were statistically significant (p < 0.05). There was no statistically significant difference in the response to treatment in relation to the duration of the disease (p > 0.05). Conclusions.Excimer light has the potential to stimulate hair regrowth in patches of alopecia areata.streszczenie Wprowadzenie. Łysienie plackowate (alopecia areata -AA) jest chorobą autoimmunologiczną charakteryzującą się atakiem limfocytów T na mieszek włosowy. Cel pracy. Ocena skuteczności światła ekscymerowego w terapii pojedynczych ognisk AA. Materiał i metodyka.Ogniska AA naświetlano 2 razy w tygodniu (ale nie w kolejnych dniach) promieniowaniem ekscymerowym (UVB) o długości fali 308 nm. U wszystkich pacjentów napromieniowywano jedną połowę ogniska, natomiast druga, osłonięta czarną gumą, służyła jako kontrola. Naświetlania rozpoczynano od dawki 300 mJ/cm 2 , którą zwiększano o 100 mJ/cm 2 podczas kolejnych naświetlań aż do uzyskania wyraźnego rumienia.A study on efficacy of 308 nm excimer light therapy in alopecia areata badania nad skutecznością promieniowania ekscymerowego o długości fali 308 nm w leczeniu łysienia plackowatego zo nun sanga, Asit Mittal

Excimer laser/light treatment of alopecia areata: A systematic review and meta‐analyses

“…The nine prospective clinical studies included 129 AA patients 11,12,16-22 ; five studies with 86 patients were CCTs with untreated control group, 11,12,17,20,21 and four studies with 43 patients were prospective clinical studies lacking control groups (Table 2). Excimer lasers were used in four studies 11,12,17,20 and excimer lights in five.…”

“…Excimer lasers were used in four studies 11,12,17,20 and excimer lights in five. 16,18,19,21,22 Five studies enrolled AA patients of all ages, 11,12,16,18,21 three studies included adults only, 19,20,22 and one study included pediatric patients only. 17 Of all patients, 109 had pAA, 18 AT, and two AU.…”

“…17 Of all patients, 109 had pAA, 18 AT, and two AU. EL treatment was performed twice weekly in five studies, 11,12,17,20,21 once weekly in two studies, 16,18 and once every 2 weeks in two studies. 19,22 Treatment duration ranged from 4 to 62 weeks (median: 12 weeks).…”

“…Cosmetically acceptable or ≥75% hair regrowth after EL treatment of all AA patients/patches was achieved in 50.2% (95% confidence interval [CI] 31.5%-68.9%) of 113 patients (eight studies). 11,12,[16][17][18][20][21][22] Hair regrowth ≥50% of all AA patients/patches was achieved in 64.0%…”

“…(95% CI 52.3%-75.7%) of 113 patients (seven studies). 11,12,17,[19][20][21][22] On subgroup analysis of pAA patients (thus, excluding those with AT or AU), cosmetically acceptable regrowth was achieved in 56.8% (95% CI 34.7%-79.1%) of 93 patients (seven studies). 11,12,[16][17][18]20,21 Hair regrowth ≥50% was achieved in 75.0% (95% CI 61.4%-88.7%) of 95…”