Treatment of a pulmonary granular cell tumour by repeated transendoscopic diode laser photoablation

Heesewijk, N. Van; Knowles, E. J.; Palgrave, Christopher J; Mair, T. S.

doi:10.1111/eve.12310

Cited by 6 publications

(5 citation statements)

References 17 publications

(30 reference statements)

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“…Of the reviewed papers, 64 contained dosing regimens for PPG (Supplementary Table 1). The most frequently reported dose was 20–25,000 IU/kg (53/64) administered every 12 h. All papers with dose rates less than this came from the UK (range 12,000–18,000 IU/kg), with the exception of one from Australia (17,000 IU/kg). Of the papers from the UK and Australia, 55% (6/11) and 20% (1/5), respectively, used doses of PPG below the most commonly reported dose of 20–25,000 IU/kg.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial dosing for common equine drugs: a content review and practical advice for veterinarians in Australia

et al. 2019

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Background Appropriate dosing with antimicrobial agents is critical for effective treatment and to prevent the development of antimicrobial resistance. Methods A review was undertaken of equine journal articles (Equine Veterinary Journal, Equine Veterinary Education, Australian Veterinary Journal, Australian Equine Veterinarian, Journal of Veterinary Internal Medicine and Journal of Equine Veterinary Science) between January 2015 and August 2018. Those with dosing regimens for procaine penicillin G, gentamicin or trimethoprim‐sulfonamide in adult horses were examined and evaluated. Pharmacokinetics and ‐dynamics of these drugs were also reviewed. Results & Conclusion The most frequently reported doses for penicillin, gentamicin and trimethoprim‐sulfonamide were 20–25,000 IU/kg, 6.6 mg/kg and 30 mg/kg, respectively. Veterinarians treating equine patients in Australia should be aware of the current recommended doses and inter‐dosing intervals to ensure efficacy in therapy and to preserve the usefulness of these antimicrobials for the future.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial dosing for common equine drugs: a content review and practical advice for veterinarians in Australia

et al. 2019

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“…A idade avançada em que os equinos costumam apresentar a neoplasia pode ser atribuída à dificuldade do estabelecimento do diagnóstico precoce, uma vez que os sinais clínicos respiratórios podem ser confundidos ou até mesmo tratados paliativamente como outro distúrbio respiratório, a exemplo da pneumonia. Isso pode resultar em animais portadores da neoplasia por longos períodos sem diagnóstico definitivo, e que, muitas vezes, será elucidado apenas ao exame anatomopatológico [11,17].…”

Section: Discussionunclassified

“…O tratamento comumente indicado para o tumor de células granulares é a ressecção cirúrgica [9]. Entretanto, o equino desta descrição foi submetido à eutanásia, tendo em vista o quadro clínico, o extenso comprometimento do parênquima pulmonar e o estado geral do animal [11,17].…”

Section: Discussionunclassified

Pulmonar Granular Cell Tumor in a Horse

Araújo

Bento

Nascente

et al. 2021

Acta Scientiae. Vet.

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Background: The occurrence of neoplasms in horses is relatively low. Granular cell tumor is a seldom diagnosed neoplasm, usually benign, of mesenchymal origin. Controversies exist regarding its origin, which is possibly from Schwann cells or cells with neuroendocrine differentiation. Despite being one of the main primary neoplasms in the lungs of horses, the number of cases is low in comparison to that of secondary lung tumors. Thus, this study proposes to report the anatomopathological aspects in a horse with granular cell tumor of primary pulmonary origin. Case: An 11-year-old female Quarter Horse breed underwent exploratory right lateral thoracotomy after presenting with chronic respiratory changes. During the operation, tumor masses were found in the right and left caudal pulmonary lobes. Due to the severity of clinical respiratory signs and the extent of the lesions, the animal was subjected to euthanasia and anatomopathological examination. Upon necroscopic examination, a tumor mass was found in the middle third of the left caudal lobe, rounded to flattened, measuring 10.0 × 8.0 cm in height and length, white in color, of firm consistency, smooth and regular surface and rising to the lung surface. When sectioned, the mass showed to be composed of multiple firm and dense circular lobes, separated by a thin layer of connective tissue. The tumor invaded the lumen of nearby segmental and subsegmental bronchi, which were partially or totally obstructed by the mass. In the right lung, multiple similar nodules were observed, accompanied by peritumoral hemorrhage. Histopathological analysis of the new formation revealed a dense cluster of cells that expanded over the lung parenchyma. The neoplastic cells were pleomorphic, moderately cohesive, without defined borders, with abundant cytoplasm, densely eosinophilic and finely granular. Intracytoplasmic granules were well evidenced by periodic acid Schiff staining (PAS). The cell nucleus was rounded to oval, excentric, markedly basophilic and with dense chromatin. There was moderate anisocytosis and mild anisokaryosis, with rare mitotic figures. Immunohistochemical analysis revealed positive staining for anti-vimentin and anti-S100 antibodies, confirming the diagnosis of granular cell tumor.Discussion: Granular cell tumors have no predisposition as to breed, sex or age. However, most of the described cases are reported in female horses aged around 13 years. The advanced age of the diagnosed animals may be related to late definitive diagnosis, since the clinical signs are nonspecific and treated palliatively like other respiratory diseases. Macroscopically, this tumor is more common in the multinodular form and, as observed in this case, it has a greater capacity for infiltration. Histologically, the visualization of large, polygonal cells, with a wide cytoplasm containing eosinophilic granules leads to the diagnosis of granular cell tumor. However, PAS staining and immunohistochemical tests were essential for the diagnostic conclusion in this report, confirming the presence of cytoplasmic granules and the mesenchymal and neuroectodermal origin of this neoplasm, respectively. Thus, considering the low occurrence of pulmonary granular cell tumor, the description of this case contributes to the basis of the knowledge of medical-veterinary professionals about this tumor in its clinical and diagnostic aspects.Keywords: Schwann cells, immunohistochemistry, neoplasia, lung.Descritores: células de Schwann, imuno-histoquímica, neoplasia, pulmão.Título: Tumor de células granulares pulmonar em um equino

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“…The report in this issue related collection of a diagnostic piece of tissue (Van Heesewijk et al . ); if convenient, the biopsy could consist of all or most of the visible tissue. Once the visible tumour has been removed, repeat radiography confirms removal of gross disease.…”

mentioning

confidence: 99%

Surgical approaches for pulmonary granular cell tumours in horses

Sullins

2015

Equine Veterinary Education

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Treatment of a pulmonary granular cell tumour by repeated transendoscopic diode laser photoablation

Cited by 6 publications

References 17 publications

Antimicrobial dosing for common equine drugs: a content review and practical advice for veterinarians in Australia

Antimicrobial dosing for common equine drugs: a content review and practical advice for veterinarians in Australia

Pulmonar Granular Cell Tumor in a Horse

Surgical approaches for pulmonary granular cell tumours in horses

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