“…However, given the difficulty of achieving these studies in veterinary medicine, case studies and retrospective or observational studies also play an important role. When confronted with a horse with suspect equine neoplasia a search of the available literature does not yield any systematic reviews or randomised controlled trials but there are many large and excellent studies on the more common tumours of the head (sinuses in particular) and urogenital system Head and Dixon 1999;Van den Top et al 2008, 2015Dixon et al 2011Dixon et al , 2012. Some papers have proposed adoption of standard diagnostic and treatment protocols as well as grading scales for equine tumours similar to human and small animal medicine but many patients are still treated without consideration of tumour grade (Van den Top et al 2008.…”