Treatment modalities of palmoplantar lichen planus: a brief review

Abstract

Palmoplantar lichen planus is a localized and uncommon variant of lichen planus which is mostly resistant to treatment. Our purpose was to discuss all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. A systematic review of the literature was conducted to evaluate evidence regarding all treatment modalities proposed and tested for palmoplantar lichen planus in the literature. Two major databases (PubMed, Google scholar) were searched. The review included all case reports, letters and original articles reporting any treatment for palmoplantar lichen planus but not treatment used in the other type of lichen planus, generalized lichen planus or other type of palmoplantar dermatoses. We have gone over more than 50 articles. There are many drugs that have been used in the treatment of lichen planus and generalized lichen planus but the palmoplantar type is a rare variety of lichen planus. That is why we could not find any clinical trial on the subject and just case reports have been described in this manuscript. In spite of plentiful investigations carried out on lichen planus, there is no treatment modality that has proved to be utterly satisfactory in treatment of palmoplantar lichen planus.

The Efficacy of Topical Coconut cream Versus Topical Triamcinolone in The Management of Oral Lichen Planus

“…The management of OLP is a very challengeable due to its chronic nature which requires a long term treatment, but generally OLP treatment is only necessary when it is symptomatic (16) . Corticosteroid is the first choice in OLP management owing to its inflammatory and immunological characters, however it is associated with numerous adverse effects, such as oral mucosa atrophy, tachyphylaxis, and candidiasis (17) .…”

Localized annular lichen planus on foot mimicking tinea pedis

“…Acitretin, enoxaparin, cyclosporine, topical cyclosporine, systemic corticosteroid, topical corticosteroid, topical tacrolimus, surgery, UVA1, db-UVB, metronidazole, retinoic acid, sulfasalazine, hydroxychloroquine, mycophenolate mofetil, and thalidomide are the treatment modalities for palmoplantar LP In the literature [13,14]. There was also a case of a positive response with topical calcineurin inhibitor therapy reported in the literature [15,16].…”

Lichen Planus: A Muco-Cutaneous, Nails and Scalp Disorder – Cases Report

“…Frequently, the lesions are well delimited, with the possibility of multiple forms in the same patient, located at the level of the internal plantar arch, usually without fingers damage. (7,8) Laboratory tests do not reveal specific changes. A leukopenia with lymphopenia, dyslipidemia, HVC positive serology or other infections may be encountered.…”

“…Systemic therapies with acitretin, cyclosporine, corticosteroids, enoxaparin and topical therapies with dermatocorticoids, retinoic acid, cyclosporine, tacrolimus/ pimecrolimus and various combinations of systemic and/ or local therapies have been shown to be effective. (13,7) CASES REPORT Case 1. Female patient, 52 years old, smoker, with a history of depressive disorder, is admitted to the dermatovenerology department for the appearance of a disseminated erythematous-papular rash for approximately 1 month.…”