Treatment and chemoprevention of NSAID-associated gastrointestinal complications

Go, Mae F.

doi:10.2147/tcrm.s1635

Cited by 4 publications

References 53 publications

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The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

Bowman

Barfield

Slone

et al. 2016

Journal of Orthopaedics

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Radial head arthroplasty (RHA) is an acceptable treatment for comminuted radial head fractures (RHF). Fourteen patients with no postop HO prophylaxis were treated with RHA for comminuted RHF. A 50% incidence in HO was seen following RHA with a statistically increased risk (p ≤ 0.05) of reoperation compared to those without HO. Decreased ROM was seen on the affected side (p ≤ 0.05); patients without HO showed no statistical difference (p ≥ 0.05) in ROM or grip strength. HO following RHA increases patient risk for reoperation and decreases ROM. We recommend HO prophylaxis with NSAIDs and/or radiotherapy if no direct patient contraindications are found.

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The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

Bowman

Barfield

Slone

et al. 2016

Journal of Orthopaedics

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Peptic ulcer disease among dyspeptic patients at endoscopy unit, University of Gondar hospital, Northwest Ethiopia

et al. 2022

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Background Dyspepsia is a common complaint in upper gastrointestinal disorders. It is described as predominant epigastric pain lasting for at least one month. Globally, peptic ulcer disease occurs in 3.5–32% of patients with dyspepsia. Helicobacter pylori (H. pylori) infection and non-steroidal anti-inflammatory drugs/aspirin use are the widely known risk factors for peptic ulcer disease. There was no recent document on H. pylori infection rate among patients with peptic ulcer disease in Ethiopia. This study aimed to determine magnitude and associated factors of peptic ulcer disease among dyspeptic patients in Northwest Ethiopia. Methods An institutional-based cross sectional study was conducted at the University of Gondar hospital, Northwest Ethiopia. A convenience sampling method was used to recruit 218 study subjects. A pre-designed semi-structured questionnaire was used to extract clinical information. Olympus flexible fiber-optic endoscope (Olympus, GIF-E 600, Olympus Corp., Hamburg, Germany) was used to confirm the presence of peptic ulcer disease. Diagnosis of active H. pylori infection was made using the fecal H. pylori Antigen 25 T Card Test (Anamol Lab., Pvt. Ltd., Palghar, India). The Data were entered into EPI Info version 4.6.0.2, and then exported to SPSS version 20 for analysis. Explanatory variables associated with peptic ulcer disease were analyzed by applying logistic regression model. P value < 0.05 was used to declare significant association. Result A total of 218 dyspeptic patients who underwent upper gastrointestinal endoscopic evaluations were included in the study. The mean (+ SD) age of patients was 42 ± 16.4 years. Forty nine percent (95% CI 42.4–56.2) of dyspeptic patients had active H. pylori infection. Peptic ulcer disease was diagnosed in 35% (95% CI 31.4–39.2) of patients with dyspepsia. H. pylori infection (AOR = 6.298, 95% CI 2.965–13.378, P value < 0.001) and NSAIDs/ASA use (AOR = 6.252, 95% CI 2.925–13.362, P value < 0.001) were identified as risk factors for peptic ulcer disease. Conclusion Medical treatment of peptic ulcer disease should target treatment of H. pylori infection and cautious use of non-steroidal anti-inflammatory drugs/aspirin.

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Smart Nano-Systems and Inflammatory Reactions

Tirelli

2013

AMR

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Inflammatory pathologies are typically characterized by an oxidizing environment. Our research aims to develop smart (nano) materials that respond to oxidizing conditions in order to establish new anti-inflammatory therapies with less side effects. For example, if drugs can be released in an inflammation-responsive fashion, it is possible to localize their action and reduce their overall amount.In this communication, we specifically focus on how polysulfide-based nanomaterials (nanoparticles, micelles) react to biological oxidants, and specifically on whether their response can depend on the identity of the oxidant. We also discuss the possibility to orientate their response and expand it to chemicals they are originally not sensitive to.

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Treatment and chemoprevention of NSAID-associated gastrointestinal complications

Cited by 4 publications

References 53 publications

The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

Peptic ulcer disease among dyspeptic patients at endoscopy unit, University of Gondar hospital, Northwest Ethiopia

Smart Nano-Systems and Inflammatory Reactions

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