Peptic ulcer disease among dyspeptic patients at endoscopy unit, University of Gondar hospital, Northwest Ethiopia

Assefa, Belete; Tadesse, Abilo; Abay, Zenahebezu; Abebe, Alula; Tesfaye, Tsebaot; Tadesse, Melaku; Molla, Ayenew

doi:10.1186/s12876-022-02245-6

Cited by 10 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Гастроэзофагеальная рефлюксная болезнь, язвенная болезнь желудка и функциональная диспепсия являются наиболее частыми причинами диспепсических симптомов. Лишь в немногих случаях диспепсические симптомы вызваны злокачественными новообразованиями ЖКТ [26][27][28].…”

Section: результатыunclassified

The problem of verification of malignant neoplasms of the stomach in surgical practice

Maksimov

Сергеев

Морозов

et al. 2022

vmirvz

View full text Add to dashboard Cite

Relevance. Despite numerous efforts made in recent decades, the arsenal of cancer diagnostics is still significantly limited.The purpose of study: to analyze the problem of differential diagnosis of early stage stomach cancer and non-oncological diseases of the abdominal cavity.Materials and methods. In the course of the work, current literary sources of domestic and foreign authors on a given topic were analyzed.Results. The early stages of malignant neoplasms of the stomach are usually asymptomatic or accompanied by nonspecific signs, such as dyspepsia. Symptoms of the development of malignant tumors of the stomach at an early stage may be indistinguishable from the symptoms of benign dyspepsia, while the presence of established "alarming" symptoms may mean a progressive inoperable disease. However, the evidence supporting the use of "alarming" symptoms as selection criteria for endoscopy still remains contradictory, since the presence of "alarming" symptoms in the clinical picture is not always associated with the detection of malignant neoplasms, it is also worth noting that the overall prevalence of these symptoms in the population of patients suffering from dyspeptic disorders is high, while while the number of patients with a history of gastrointestinal cancer is relatively low.Conclusion. Despite the observed trend of decreasing morbidity and mortality, malignant neoplasms of the stomach remain an important part in the structure of oncological diseases. Many of the risk factors remain insufficiently studied and should be the subject of further research to achieve more specific, targeted preventive measures.

show abstract

Section: результатыunclassified

The problem of verification of malignant neoplasms of the stomach in surgical practice

Maksimov

Сергеев

Морозов

et al. 2022

vmirvz

View full text Add to dashboard Cite

show abstract

“…В этиопатогенезе ЯБЖ вовлечены множество внешних и внутренних факторов риска (неправильный режим употребления пищи, бесконтрольный прием антибиотиков, индуцирующий выживание самых агрессивных штаммов Helicobacter pylori (Н. pylori), частое применение нестероидных противовоспалительных средств (НПВС), разрушающих защитный слой слизистой оболочки желудка, стрессовый фактор, курение, прием алкоголя и др. ), так и наследственные факторы [4,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. По различным данным, вклад наследственности в этиопатогенез заболевания составляет от 5,5 до 50% [29].…”

Section: Introductionunclassified

Contribution of intergenic interactions of polymorphic variants of candidate genes to the development of a gastric ulcer

Рашина

Чурносов

2023

jour

View full text Add to dashboard Cite

Introduction: Peptic ulcer disease occurs in 5-10% of the adult population, and is characterized by a high percentage of complications, which is a serious medical and social problem. The contribution of hereditary factors to the etiopathogenesis of the disease leaves 5.5-50%. The aim of the study was to study the contribution of intergenic interactions of polymorphic variants of candidate genes (rs2294008, rs505922, rs6136, rs8176720, rs2519093, rs507666, rs651007, rs579459, rs649129) to the development of gastric ulcer (GU). Materials and methods: The sample consisted of 217 patients with GU and 347 individuals from the control group, the regulatory potential of polymorphic loci were evaluated using the online databases, and genotyping was performed by PCR. The study of SNP×SNP interactions of polymorphic variants of candidate genes associated with the development of GU was carried out using a modification of the MDR (Multifactor Dimensionality Reduction) - Model-Based-MDR (MB-MDR) method, data visualization was carried out in the form of a dendrogram and graph using MDR software (v. 3.0.2). Results: All 9 studied SNPs as part of 10 significant models of interlocus interactions are involved in the formation of GU. The largest number of models includes rs8176720 of the ABO gene and rs2294008 of the PSCA gene. These polymorphic variants have a pronounced regulatory potential in many organs (tissues), incl. in the target organ of GU (stomach).

show abstract

“…A study showed that 4.4 billion people (57.9% of the global population at that time) were infected with H. pylori in 2017 (11). and global reports show that the prevalence of H. pylori infection in patients with PUD is 14-21% in the United States, 60-70% in Asia, and 70-90% in sub-Saharan Africa (12,13). Therefore, worldwide consensus guidelines recommend mandatory H. pylori eradication in patients with PUD (14).…”

Section: Introductionmentioning

confidence: 99%

“…and global reports show that the prevalence of H . pylori infection in patients with PUD is 14–21% in the United States, 60–70% in Asia, and 70–90% in sub-Saharan Africa ( 12 , 13 ). Therefore, worldwide consensus guidelines recommend mandatory H .…”

Section: Introductionmentioning

confidence: 99%

Analysis of risk factors for ulcer recurrence and upper gastrointestinal bleeding in children with peptic ulcer treated with Helicobacter pylori eradication therapy

Li¹,

Wang²,

Ma³

et al. 2023

Transl Pediatr

View full text Add to dashboard Cite

Background: The incidence of peptic ulcer disease (PUD) has been increasing yearly, especially in the adolescent population. The eradication of Helicobacter pylori (H. pylori) may reduce recurrence and bleeding to some extent, but it does not completely change the clinical status of PUD. Therefore, this study aims to analyze the risk factors for ulcer recurrence and upper gastrointestinal bleeding after H. pylori eradication therapy in order to provide a reference for reducing the risk of PUD and improving the quality of life of patients.Methods: We retrospectively analyzed 536 adolescent patients who developed peptic ulcer and received H. pylori eradication therapy from June 2016 to July 2021. The relationship between the clinical characteristics of the patients and gastrointestinal bleeding and recurrence was analyzed using the t test and chi-squared test.Binary logistic regression was used to analyze the independent risk factors for the occurrence of bleeding and recurrence.Results: A total of 536 patients were included in this retrospective study. Gender, history of ulcers, number, size, location and staging of ulcers, and application of nonsteroidal anti-inflammatory drugs (NSAIDs), and other characteristics were significantly different between the bleeding and nonbleeding groups (P<0.05); family history of upper gastrointestinal ulcer, history of ulcers, number and size of ulcers and application of NSAIDs, and other characteristics were significantly different between the recurrent and nonrecurrent groups (P<0.05). Binary logistic regression analysis showed that history of ulcers, number and location of ulcers, coagulation abnormalities, and other characteristics were independent risk factors for the occurrence of bleeding; the occurrence of previous bleeding, number and size of ulcers, and other characteristics were independent risk factors for recurrence. Conclusions:In the clinical treatment of adolescent patients, it is important to pay high attention to clinical characteristics, such as the patient's previous ulcer history, the size, number and location of ulcers, and coagulation function, so as to adopt individualized treatment methods to effectively reduce the harmfulness of the disease in response to the risk factors of ulcer bleeding and recurrence after H. pylori eradication therapy. This can decrease the occurrence of complications and improve the prognosis of patients.

show abstract

Peptic ulcer disease among dyspeptic patients at endoscopy unit, University of Gondar hospital, Northwest Ethiopia

Cited by 10 publications

References 31 publications

The problem of verification of malignant neoplasms of the stomach in surgical practice

The problem of verification of malignant neoplasms of the stomach in surgical practice

Contribution of intergenic interactions of polymorphic variants of candidate genes to the development of a gastric ulcer

Analysis of risk factors for ulcer recurrence and upper gastrointestinal bleeding in children with peptic ulcer treated with Helicobacter pylori eradication therapy

Contact Info

Product

Resources

About