The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

Bowman, Seth; Barfield, William R.; Slone, Harris S.; Shealy, Gerald; Walton, Zeke J.

doi:10.1016/j.jor.2016.06.011

Cited by 12 publications

(6 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heterotopic ossification is a frequent complication associated with post-traumatic healing in clinical conditions such as fractures, spinal cord injury, traumatic brain injury, blast injuries, severe burns, and extensive surgeries, such as hip arthroplasty, acetabular, and elbow surgeries. 1–4 In addition to trauma-induced localized HO as described above, this pathological phenomenon is also seen systemically in a rare genetic disorder, ‘Fibrodysplasia Ossificans Progressiva’ (FOP), where heterotopic bone forms in soft tissues and joints, either sporadically or in response to an external trauma. 5 Interestingly, in both nongenetic and genetic cases, this bone forms at sites with a high concentration of connective tissue cells (perimysium, periosteum, peritenon) and entheses.…”

Section: Trauma-related Ho: Definition and Epidemiologymentioning

confidence: 99%

The traumatic bone: trauma-induced heterotopic ossification

Dey

Wheatley

Cholok

et al. 2017

Translational Research

106

108

View full text Add to dashboard Cite

Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive burns in the civilian setting, and combat-related extremity injuries in the battlefield. Irrespective of the form of trauma, heterotopic bone is typically endochondral in structure and is laid down via a cartilaginous matrix. Once formed, the heterotopic bone typically needs to be excised surgically, which may result in wound healing complications, in addition to a risk of recurrence. Refinements of existing diagnostic modalities, like micro- and nano-CT are being adapted toward early intervention. Trauma-induced HO is a consequence of aberrant wound healing, systemic and local immune system activation, infections, extensive vascularization, and innervation. This intricate molecular crosstalk culminates in activation of stem cells that initiate heterotopic endochondral ossification. Development of animal models recapitulating the unique traumatic injuries has greatly facilitated the mechanistic understanding of trauma-induced HO. These same models also serve as powerful tools to test the efficacy of small molecules which specifically target the molecular pathways underlying ectopic ossification. This review summarizes the recent advances in the molecular understanding, diagnostic and treatment modalities in the field of trauma-induced HO.

show abstract

Section: Trauma-related Ho: Definition and Epidemiologymentioning

confidence: 99%

The traumatic bone: trauma-induced heterotopic ossification

Dey

Wheatley

Cholok

et al. 2017

Translational Research

106

108

View full text Add to dashboard Cite

show abstract

“…19 Assessment included the position of the stem for the stemmed components which was considered to be valgus or varus when the distal extremity apposed the lateral or medial aspect of the radial cortex, respectively, signs of periprosthetic osteolysis (Fig. 2), heterotopic ossification according to the Brooker classification, 35,36 and capitellar wear. These were noted at each post-operative review.…”

Section: Figmentioning

confidence: 99%

Mid-term outcomes of 77 modular radial head prostheses

Laumonerie

Reina

Ancelin

et al. 2017

The Bone & Joint Journal

View full text Add to dashboard Cite

show abstract

“…The occurrence of HO was reported at the variable rate following the radial head replacement. 19,20,43 Bowman et al observed that the patients who developed HO after radial head replacement had a statistically significant postoperative ROM deficits. 43 In our study, one of the patients who developed HO had restricted forearm pronation.…”

Section: Discussionmentioning

confidence: 99%

Radial head replacement with the 3D-printed patient-specific titanium prosthesis: Preliminary results of a multi-centric prospective study

Luenam,

Kosiyatrakul,

Charoenlap

et al. 2024

J Orthop Surg (Hong Kong)

View full text Add to dashboard Cite

Purpose To report preliminary clinical results and safety of 3D-printed patient-specific titanium radial head (RH) prosthesis in treatment of the irreparable RH fractures. Material and methods This multi-centric prospective study included 10 patients (6 men and four women, mean age 41 years (range, 25–64 years)). Three cases were classified as Mason type III and 7 cases as type IV. Patients were assessed preoperatively, intraoperatively, and at 1, 6, 12, 24, 36, and 48 weeks postoperatively. Range of motion (ROM), visual analog scale (VAS) score, Disabilities of the Arm, Shoulder and Hand (DASH) score, Mayo Elbow Performance Score (MEPS), radiology imaging, and laboratory blood and urine testing were evaluated. Results The prostheses were implanted utilizing cemented stems in 5 patients and cementless stems in 5 patients. Intraoperatively, well congruency of a prosthesis with capitellum and radial notch of ulna was observed in all cases. All patients had improvement of ROM, VAS score, DASH score, and MEPS during the postoperative follow-ups. At the final follow-up, mean elbow extension was 6.5° (range, 0°–30°), flexion 145° (range, 125°–150°), supination 79° (range, 70°–80°), and pronation 73.5° (range, 45°–80°). Mean VAS score was 0.3 (range, 0–3), DASH score was 12.35 (range, 1.7–23.3), and MEPS was 99.5 (range, 95–100). Postoperative radiographs demonstrated heterotopic ossification in 2 cases, periprosthetic radiolucency in 2 cases, and proximal radial neck resorption in 2 cases. No one had the evidence of capitellar erosion, implant failure, malpositioning, overstuffing, or symptomatic stem loosening. There was no significant alteration of laboratory results or adverse events related to the 3D-printed prosthesis implantation. Conclusion The preliminary results demonstrated that implantation of the 3D-printed patient-specific titanium RH prosthesis is safe and may be a potential treatment option for irreparable RH fracture.

show abstract

The clinical implications of heterotopic ossification in patients treated with radial head replacement for trauma: A case series and review of the literature

Cited by 12 publications

References 52 publications

The traumatic bone: trauma-induced heterotopic ossification

The traumatic bone: trauma-induced heterotopic ossification

Mid-term outcomes of 77 modular radial head prostheses

Radial head replacement with the 3D-printed patient-specific titanium prosthesis: Preliminary results of a multi-centric prospective study

Contact Info

Product

Resources

About