Traumatic ulcerative eosinophillic granuloma with stromal eosinophilia of tongue

Chavan, Sateesh S; Reddy, Purushotham

doi:10.4103/2278-330x.114128

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…Any ulcer which does not heal for more than 2 weeks alerts the clinician to exclude the possibility of malignancy. 8 It exhibits a slight female predominance with bimodal distribution and a peak incidence between the sixth and seventh decades of life. 1 In our cases, solitary non-healing ulcers were seen in all with a duration of two weeks to three months and sizes ranging from 0.7 to 1.5 cm.…”

Section: Discussionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature

Mehta

Muthusamy

2020

J Pathol Nep

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Most of the oral ulcers are traumatic in origin due to sharp tooth and self bite. Traumatic ulcerative granuloma with stromal eosinophilia is a chronic benign lesion of the oral mucosa with uncertain histogenesis. Trauma was proposed to be an inciting factor. A series of four cases of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the lateral borders of the tongue were analyzed regarding oral hygiene, sharp tooth, clinical presentation, histology, and follow-up. The lesion manifests as a small solitary ulcer with induration in the oral mucosa mimicking malignancy. Histology revealed ulcers with exudate and granulation tissue with dense polymorphous infiltrate rich in eosinophils. Infiltrate extends down in between the skeletal muscle fibers and salivary gland lobules. A sharp tooth was found to be the inciting factor in a proportion of cases. Histopathological examination is mandatory to confirm the diagnosis and to exclude malignancy and other eosinophil rich disorders.

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Section: Discussionmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature

Mehta

Muthusamy

2020

J Pathol Nep

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“…Det er også hev det at eosi no fi le gra nu lo cyt ter pro du se rer «Tu mor Nek ro se Fak tor» (TNF) som fø rer til vevs ska de (1). Det kan vaere at cy to tok sis ke T cel ler og tok sis ke produker fra de gra nu le ring av eosi no fi le gra nu lo cyt ter fø rer til for sin ket til he ling (18).…”

Section: Etio Lo Giunclassified

Sår i munnhulen som ikke vil tilhele kan være traumatisk ulcerativt granulom med stromal eosinofili (TUGSE)

Søland¹,

Andersen²,

Solheim³

2019

Tidende

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Det hen der at sår i munn hu len ikke vil gro av seg selv i lø pet av ri me lig tid. Ofte har dis se voll for me de kan ter og tann le gen kan få inn trykk av at det kan vaere et plateepitelkarsinom. Det te kan vaere Trau ma tisk Ul ce rert Gra nu lom med Stromal Eeosinofili (TUGSE).Dis se to ka sus er eks emp ler. Skrift lig sam tyk ke til pub li se ring er inn hen tet fra beg ge pa si en ter Pa si ent nr 1 var en 89 år gam mel kvin ne.Pa si en ten var hen vist til Co los se um kli nik ken, avd. Tøns berg for ut red ning og even tu ell be hand ling av et sår i ora le slim hin ne retro molart i venst re over kje ve (fi gur 1). Så ret var sir ku laert og kro ne styk kestort med voldformet pe ri fe ri. Ul ce ra sjo nen var lett fik sert mot un der laget. Pa si en ten had de mer ket så ret for ca en mnd si den, men tro lig had de det per sis tert len ger. Det kun ne ikke pal pe res for stør re de sub man di bu lae re el ler cer vi ka le lym fe kjert ler.Kli nisk dia gno se: Ma jor afte/Plateepitelkarsinom For and rin gen ble opp da get av hen vi ser 3 uker før kon sul ta sjo nen hos spe sia list og had de ikke for and ret seg i pe ri oden. Pa si en ten be skrev kun be skje d ne symp to mer i form av sår het. Hun had de høyt blod trykk, var rev ma tisk og had de Dia be tes type 2. Hun bruk te Arthrotec, Me to pro lol, Pa ra ce ta mol, Elocon, Travatan og Tra ma dol.Det ble tatt insisjonsbiopsi som ble sendt Cito for his to lo gisk un der sø kel se til Oslo Uni ver si tets sy ke hus HF Riks hos pi ta let, Av de FORFATTERE Tine M. Søland, førsteamanuensis, Institutt for oral biologi, Det odontologiske fakultet, Universitetet i Oslo og Avdeling for patologi, Oslo universitetssykehus. Eivind Andersen, Spesialist i oral kirurgi og oral medisin, Farmandstredet, 3110 Tønsberg. Tore Solheim, professor emeritus, Institutt for oral biologi, Det odontologiske fakultet, Universitetet i Oslo.

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“…The lesion characteristically has fi rm margins along with fast occurrence and slow healing; it can be confused with oral malignancy such as squamous cell carcinoma. [6] In the literature, the pathogenesis of TUGSE was mainly trauma leading to ulceration, hence ingress of viral/toxic agents/ foreign bodies induces an exaggerated infl ammatory reaction leading to release of mast cells and eosinophils. [7,8] The degranulation of mast cells leads to release of mediators, which causes infl ammation and also attracts eosinophils by release of eosinophil chemotactic factor of anaphylaxis.…”

Section: Case Reportmentioning

confidence: 99%

Traumatic ulcerative granuloma with stromal eosinophilia: A diagnostic dilemma?

Nagaraj¹,

Okade²,

Sinha³

et al. 2014

JCRI

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Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a slow growing reactive lesion that commonly aff ects the tongue. The pathogenesis of this lesion is obscure. Chronic irritation from traumatic agents is considered to be one of the contributing factors in most of the cases. It usually presents as an ulcer or an indurated submucosal mass. Histopathologically, it is characterized by eosinophilic infl ammatory infi ltrate penetrating into the submucosal layers degenerating the underlying muscle. It is important to recognize this mucosal entity as it has a close resemblance with malignancy of the oral cavity. The pathognomonic feature of TUGSE is that it resolves on its own after excisional biopsy. A 25-year-old Sudanese boy had reported to us with an ulceroproliferative growth in the left side of the mouth.

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Traumatic ulcerative eosinophillic granuloma with stromal eosinophilia of tongue

Cited by 8 publications

References 9 publications

Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature

Traumatic ulcerative granuloma with stromal eosinophilia: a series of four cases with review of literature

Sår i munnhulen som ikke vil tilhele kan være traumatisk ulcerativt granulom med stromal eosinofili (TUGSE)

Traumatic ulcerative granuloma with stromal eosinophilia: A diagnostic dilemma?

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