Trauma Wound Related Infection Caused by &lt;i&gt;Enterobacter cancerogenus&lt;/i&gt; and &lt;i&gt;Aeromonas hydrophilia&lt;/i&gt;

Hadano, Yoshiro; Tamagawa, Keiichi; Ohkusu, Kiyofumi

doi:10.2169/internalmedicine.9171-17

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…These species are especially described in ICUs, as previously mentioned, and have also been involved in sepsis occurring in neonatology (164,165). Moreover, E. hormaechei has also been identified in intravascular device-related infections, in surgical site infections (primarily postoperative in orthopedic trauma or related to devices), and, notably, after organ transplants (160,(166)(167)(168)(169)(170)(171).…”

Section: Clinical Manifestationsmentioning

confidence: 94%

Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

2019

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SUMMARY The genus Enterobacter is a member of the ESKAPE group, which contains the major resistant bacterial pathogens. First described in 1960, this group member has proven to be more complex as a result of the exponential evolution of phenotypic and genotypic methods. Today, 22 species belong to the Enterobacter genus. These species are described in the environment and have been reported as opportunistic pathogens in plants, animals, and humans. The pathogenicity/virulence of this bacterium remains rather unclear due to the limited amount of work performed to date in this field. In contrast, its resistance against antibacterial agents has been extensively studied. In the face of antibiotic treatment, it is able to manage different mechanisms of resistance via various local and global regulator genes and the modulation of the expression of different proteins, including enzymes (β-lactamases, etc.) or membrane transporters, such as porins and efflux pumps. During various hospital outbreaks, the Enterobacter aerogenes and E. cloacae complex exhibited a multidrug-resistant phenotype, which has stimulated questions about the role of cascade regulation in the emergence of these well-adapted clones.

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Section: Clinical Manifestationsmentioning

confidence: 94%

Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

2019

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“…Aeromonas species have been detected by the pus culture of infected wounds contained in a 12-year-old boy that had injured his knees after falling on rocks while swinging over water ( Rutteman, 2017 ). Likewise, A. hydrophila and E. cancerogenus were also identified in the pus culture of an elderly patient who suffered a traffic accident and fell into a pool of contaminated water ( Hadano et al, 2017 ). Traumatic events involving sharp objects have also been the cause of infections by these bacteria ( Larka et al, 2003 ).…”

Section: Pathological Processes and Clinical Manifestationsmentioning

confidence: 99%

Aeromonas and Human Health Disorders: Clinical Approaches

et al. 2022

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The genus Aeromonas comprises more than 30 Gram-negative bacterial species and naturally inhabitants from aquatic environments. These microorganisms, commonly regarded as pathogens of fish and several other animals, have been gaining prominence on medical trial due to its ability to colonize and infect human beings. Besides water, Aeromonas are widely spreaded on most varied sources like soil, vegetables, and food; Although its opportunistic nature, they are able to cause infections on immunocompromised or immunocompetent patients. Aeromonas species regarded as potential human pathogens are usually A. hydrophila, A. caviae, and A. veronii biovar sobria. The main clinical manifestations are gastrointestinal tract disorders, wound, and soft tissue infections, as well as septicemia. Regarding to antibiotic responses, the bacteria present a diversified susceptibility profile and show inherence resistance to ampicillin. Aeromonas, as an ascending genus in microbiology, has been carefully studied aiming comprehension and development of methods for detection and medical intervention of infectious processes, not fully elucidated in medicine. This review focuses on current clinical knowledge related to human health disorders caused by Aeromonas to contribute on development of efficient approaches able to recognize and impair the pathological processes.

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“…A non-typeable plasmid harbored bla CTX-M-14 , bla TEM-1B , bla OXA-1 , catB3 (phenicols resistance) and sul1 (sulfonamide resistance) [ 371 ]. Subsequently, E. cancerogenus was reported as a seriously aggressive infectious agent in skin wounds caused by mechanical trauma [ 372 ].…”

Section: Eskape and Wound Infectionsmentioning

confidence: 99%

Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance

et al. 2021

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The skin is the largest organ in the human body, acting as a physical and immunological barrier against pathogenic microorganisms. The cutaneous lesions constitute a gateway for microbial contamination that can lead to chronic wounds and other invasive infections. Chronic wounds are considered as serious public health problems due the related social, psychological and economic consequences. The group of bacteria known as ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter sp.) are among the most prevalent bacteria in cutaneous infections. These pathogens have a high level of incidence in hospital environments and several strains present phenotypes of multidrug resistance. In this review, we discuss some important aspects of skin immunology and the involvement of ESKAPE in wound infections. First, we introduce some fundamental aspects of skin physiology and immunology related to cutaneous infections. Following this, the major virulence factors involved in colonization and tissue damage are highlighted, as well as the most frequently detected antimicrobial resistance genes. ESKAPE pathogens express several virulence determinants that overcome the skin’s physical and immunological barriers, enabling them to cause severe wound infections. The high ability these bacteria to acquire resistance is alarming, particularly in the hospital settings where immunocompromised individuals are exposed to these pathogens. Knowledge about the virulence and resistance markers of these species is important in order to develop new strategies to detect and treat their associated infections.

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Trauma Wound Related Infection Caused by <i>Enterobacter cancerogenus</i> and <i>Aeromonas hydrophilia</i>

Cited by 6 publications

References 13 publications

Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

Enterobacter spp.: Update on Taxonomy, Clinical Aspects, and Emerging Antimicrobial Resistance

Aeromonas and Human Health Disorders: Clinical Approaches

Interplay between ESKAPE Pathogens and Immunity in Skin Infections: An Overview of the Major Determinants of Virulence and Antibiotic Resistance

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