8In the setting of emerging approaches for material design, we investigate the use of 9 extended finite element method (XFEM) to predict the behavior of a newly designed bone-10 inspired fiber-reinforced composite and to elucidate the role of the characteristic 11 microstructural features and interfaces on the overall fracture behavior. The outcome of the 12 simulations, showing a good agreement with the experimental results, reveals the 13 fundamental role played by the heterogeneous microstructure in altering the stress field, 14 reducing the stress concentration at the crack tip, and the crucial role of the interface region 15 (i.e. cement line) in fostering the activation of characteristic toughening mechanisms, thus 16 increasing the overall flaw tolerance of the composite.17 18 Keywords: 19 B. Fracture 20 C. Numerical analysis; Computational modeling; 21 XFEM (Extended Finite Element Method) 22 23 24 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 2 2 of ideal design, being simultaneously lightweight, stiff, strong and tough. Examples are 3 bone, which provides supports to many animal bodies, nacre and seashells, working as 4 natural body armors and providing protection from external predators' attacks, bamboo, 5 whose gradient structure guarantees an augmented flexural rigidity, enabling protection 6 from crosswind and gravity. Ancient but ever-intriguing, these materials are paradigms of 7 natural structural composites, made of few universal constituents and achieving -through a 8 sophisticated design -a unique combination of mechanical properties, bypassing the trade-9 off faced by synthetic engineering materials [1]. Traditional structural materials, indeed, 10 continuously face a typical engineering issue of satisfying both strength and toughness 11 requirements. For instance, ceramics provide high strength with a low toughness, whereas 12 steel and metals have high toughness and a limited strength. Composites often represent a 13 good compromise, being lightweight and stiff and offering a good balance with strength-14 toughness [2]. In particular, fiber-reinforced composites, which present the highest 15 stiffness-to-weight and strength-to-weight ratio, represent an attractive solution for 16 structural applications where the weight is a crucial aspect (e.g. automotive and aerospace) 17 [3-5]. However, they often fail in a brittle way. Enhancing the fracture toughness, by 18 promoting larger energy release before failure, will increase the intrinsic safety of such 19 materials, also fostering their adoption for diverse structural applications. 20 Drawing inspiration from nature can offer a path towards enhancing their resistance 21 to fracture. Bone, in particular, may represent an excellent biomimetic model for novel 22 composite design. Bone is a lightweight strong and tough natural composite made of 23 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 hydroxyapatite mineral crystals, providing stiffness and strength, interspersed into an 1 organic matrix (mainly made of collagen) th...