Transurethral illumination probe design for deep photoacoustic imaging of prostate

Ai, Min; Tang, Shuo; Salcudean, Tim; Rohling, Robert; Abolmaesumi, Purang

doi:10.1117/12.2291164

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…With regard to performance, the sandpaper-abraded fiber diffuser presented here has a radially-uniform emission profile similar to the laser micro-machined fiber diffuser [65]. Additionally, the radial emission profiles of the acid-etched fiber diffusers qualitatively appear uniform, while the longitudinal emission profiles also appear to have a peak [37,64]. Based on these results, our cylindrically-diffusing MMF design has a similar performance regarding the emission profile at a low coupling angle.…”

Section: Design Of the Transurethral Illumination Source And Light Cosupporting

confidence: 55%

“…The benefits of sandpaper abrasion compared to laser micro-machining are that the sensitive alignment of a laser is not needed, and the only equipment needed to make the diffuser fiber here is sandpaper. This fabrication method is also safer and faster compared to the use of etching agent for abrading the surface or creating tapered fiber ends [37,64]. With regard to performance, the sandpaper-abraded fiber diffuser presented here has a radially-uniform emission profile similar to the laser micro-machined fiber diffuser [65].…”

Section: Design Of the Transurethral Illumination Source And Light Comentioning

confidence: 95%

“…combination of PAT and US imaging can then provide spectroscopic and anatomical information [34][35][36][37][38][39][40]42,43]. Angiogenesis and lipid accumulation have been shown to be increased in prostate cancer tumors [58,59].…”

mentioning

confidence: 99%

“…The second location, which shows improved potential for PAT of the anterior prostate [60], is to deliver light via the prostatic urethra. A couple of transurethral light delivery designs have been employed for transrectal prostate PAT imaging, including a bevel-tipped fiber [61] and a fiber with a diffuser end [37]. While the recently published transurethral illumination device with diffuser end improved the illumination volume [37], neither of these transurethral light delivery designs has demonstrated the ability to deliver enough light uniformly for whole-prostate illumination, which is ideal since the detector and illumination source are separated.…”

mentioning

confidence: 99%

“…While cylindrical diffusers have been used for photodynamic therapy for decades [62,63], their application in PAT is just emerging [37,41,64]. The process of fabricating a cylindrical diffuser typically entails methods that use acid etching [37,64] or laser micro-machining with a uniform pattern created on the fiber surface [65]. Using the acid etching method, Ai et al created a 3.0 cm long diffuser on the end of a 1.0 mm core multimode fiber (MMF).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Bungart¹,

Cao²,

Yang-Tran³

et al. 2019

Biomed. Opt. Express

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Current diagnosis of prostate cancer relies on histological analysis of tissue samples acquired by biopsy, which could benefit from real-time identification of suspicious lesions. Photoacoustic tomography has the potential to provide real-time targets for prostate biopsy guidance with chemical selectivity, but light delivered from the rectal cavity has been unable to penetrate to the anterior prostate. To overcome this barrier, a urethral device with cylindrical illumination is developed for whole-prostate imaging, and its performance as a function of angular light coupling is evaluated with a prostate-mimicking phantom.

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Section: Design Of the Transurethral Illumination Source And Light Cosupporting

confidence: 55%

Section: Design Of the Transurethral Illumination Source And Light Comentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Bungart¹,

Cao²,

Yang-Tran³

et al. 2019

Biomed. Opt. Express

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Photoacoustic imaging of a human vertebra: implications for guiding spinal fusion surgeries

Shubert

Bell

2018

Phys. Med. Biol.

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It is well known that there are structural differences between cortical and cancellous bone. However, spinal surgeons currently have no reliable method to non-invasively determine these differences in real-time when choosing the optimal starting point and trajectory to insert pedicle screws and avoid surgical complications associated with breached or weakened bone. This paper explores 3D photoacoustic imaging of a human vertebra to noninvasively differentiate cortical from cancellous bone for this surgical task. We observed that signals from the cortical bone tend to appear as compact, high-amplitude signals, while signals from the cancellous bone have lower amplitudes and are more diffuse. In addition, we discovered that the location of the light source for photoacoustic imaging is a critical parameter that can be adjusted to non-invasively determine the optimal entry point into the pedicle. Once inside the pedicle, statistically significant differences in the contrast and SNR of signals originating from the cancellous core of the pedicle (when compared to signals originating from the surrounding cortical bone) were obtained with laser energies of 0.23-2.08 mJ (p < 0.05). Similar quantitative differences were observed with an energy of 1.57 mJ at distances ⩾6 mm from the cortical bone of the pedicle. These quantifiable differences between cortical and cancellous bone (when imaging with an ultrasound probe in direct contact with each bone type) can potentially be used to ensure an optimal trajectory during surgery. Our results are promising for the introduction and development of photoacoustic imaging systems to overcome a wide range of longstanding challenges with spinal surgeries, including challenges with the occurrence of bone breaches due to misplaced pedicle screws.

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Toward Robot-Assisted Photoacoustic Imaging: Implementation Using the da Vinci Research Kit and Virtual Fixtures

Moradi

Tang

Salcudean

2019

IEEE Robot. Autom. Lett.

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Transurethral illumination probe design for deep photoacoustic imaging of prostate

Cited by 4 publications

References 11 publications

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Photoacoustic imaging of a human vertebra: implications for guiding spinal fusion surgeries

Toward Robot-Assisted Photoacoustic Imaging: Implementation Using the da Vinci Research Kit and Virtual Fixtures

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