Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Bungart, Brittani; Cao, Yanguang; Yang-Tran, Tiffany; Gorsky, Sean; Lan, Lu; Roblyer, Darren; Koch, Michaël; Liu, Cheng; Masterson, Timothy A.; Cheng, Ji‐Xin

doi:10.1364/boe.10.001405

Cited by 10 publications

(10 citation statements)

References 80 publications

(59 reference statements)

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“…To make a radial-emission fiber diffuser, the jacket and cladding of an optical fiber are removed, and the surface of the fiber core is roughened to scatter the light out. 47 , 48 , 88 The fiber core can also be coated with a layer of optically scattering particles to further homogenize the light emission. 50 , 89 , 90 In contrast, a frontal diffuser is typically separable from the optical fiber.…”

Section: Technical Advancements In Molecular Patmentioning

confidence: 99%

“… 40 - 43 Numerous efforts have been made by various research groups to address the aforementioned challenges. Through careful selection of excitation wavelength, 44 - 46 optimization of light delivery, 47 - 50 and sophisticated design and fabrication of the ultrasonic transducer, 51 - 55 the penetration depth of PAT has been substantially improved. Moreover, by increasing the imaging speed or frame rate, PAT can reduce the motion artifacts and improve the detection sensitivity with signal averaging, leading to larger imaging depth.…”

Section: Introductionmentioning

confidence: 99%

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Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Nyayapathi

Kilian

et al. 2020

Mol Imaging

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Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed.

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Section: Technical Advancements In Molecular Patmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Nyayapathi

Kilian

et al. 2020

Mol Imaging

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“…Specifically, the lipid-specific contrast is generated endogenously from the first overtone absorption of C-H bonds at 1720 nm wavelength (the detail information of absorption spectrum were shown in supporting Figure S1), and the PA signal of lipid is one order of magnitude greater than that of water and connective tissues at this wavelength, 17,18 which makes IVPA imaging a promising technology for mapping and assessing the lipid over the entire artery wall. [19][20][21][22][23] Although IVPA imaging is constantly developing, the current IVPA researches still focus on improving resolution, imaging depth, and imaging speed. [24][25][26][27][28] The latest researches showed that the IVPA endoscopic system has the best lateral resolution of 13 μm and has the ultrafine imaging catheter with a diameter of 0.7 mm.…”

Section: Introductionmentioning

confidence: 99%

“…The sensitivity, specificity, and accuracy of IVPA are valuable to be investigated as it is an essential step for clinical translation of IVPA imaging. Specifically, the lipid‐specific contrast is generated endogenously from the first overtone absorption of C‐H bonds at 1720 nm wavelength (the detail information of absorption spectrum were shown in supporting Figure S1), and the PA signal of lipid is one order of magnitude greater than that of water and connective tissues at this wavelength, 17, 18 which makes IVPA imaging a promising technology for mapping and assessing the lipid over the entire artery wall 19–23 …”

Section: Introductionmentioning

confidence: 99%

Reliability assessment on intravascular photoacoustic imaging of lipid: ex vivo animal and human sample validation

Peng

Hao

Wang

et al. 2020

Journal of Biophotonics

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Although the lipid-detecting IVPA imaging system has been developed in resolution, speed, and catheter size, there is no parameterization study of the reliability on the IVPA imaging for lipid diagnosis. Here, the sensitivity, specificity, and accuracy were calculated to assess the reliability of the IVPA imaging of lipid. Abdominal aortas from six rabbits with atherosclerosis, were subjected to the IVPA imaging and Oil Red O staining, and 75 groups of IVPA as well as corresponding histological images were obtained. Similarly, 125 groups of IVPA and histological results were obtained from five human carotid plaque samples. The sensitivity, specificity, and accuracy, calculated from the statistical data, were 96.8%, 83.3%, 94.6% and 97.3%, 72.7%, 95.2%, respectively. The numerical values of sensitivity, specificity, and accuracy demonstrated the reliability of IVPA imaging on distinguishing the lesions vessel with lipid-rich plaque, which provided the foundation for IVPA translation to clinical application.

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“…However, APORs can only support low laser energies and US transmission through the reflector is highly angle-dependent [ 29 – 31 ]. Other illumination methods for deep tissue illumination include internal illuminations [ 32 , 33 ]. However, internal illumination is difficult to develop for breast imaging applications.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies

et al. 2019

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Photoacoustic (PA) imaging is a methodology that uses the absorption of short laser pulses by endogenous or exogenous chromophores within human tissue, and the subsequent generation of acoustic waves acquired by an ultrasound (US) transducer, to form an image that can provide functional and molecular information. Amongst the various types of PA imaging, PA tomography (PAT) has been proposed for imaging pathologies such as breast cancer. However, the main challenge for PAT imaging is the deliverance of sufficient light energy horizontally through an imaging cross-section as well as vertically. In this study, three different illumination methods are compared for a full-ring ultrasound (US) PAT system. The three distinct illumination setups are full-ring, diffused-beam, and point source illumination. The full-ring system utilizes a cone mirror and parabolic reflector to create the ringed-shaped beam for PAT, while the diffuse scheme uses a light diffuser to expand the beam, which illuminates tissue-mimicking phantoms. The results indicate that the full-ring illumination is capable of providing a more uniform fluence irrespective of the vertical depth of the imaged cross-section, while the point source and diffused illumination methods provide a higher fluence at regions closer to the point of entry, which diminishes with depth. In addition, a set of experiments was conducted to determine the optimum position of ring-illumination with respect to the position of the acoustic detectors to achieve the highest signal-to-noise ratio.

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Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography

Cited by 10 publications

References 80 publications

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Reliability assessment on intravascular photoacoustic imaging of lipid: ex vivo animal and human sample validation

Photoacoustic Tomography with a Ring Ultrasound Transducer: A Comparison of Different Illumination Strategies

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