Transrectal sonographic features of prostatic intraepithelial neoplasia: Correlation with pathologic findings

Özden, Eriz; Göğüş, Çağatay; Karamürsel, Tamer; Baltacı, Sümer; Küpeli, Sadettin; Göğüş, Orhan

doi:10.1002/jcu.20080

Cited by 7 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We divided them into two types of lesions: (1). premalignant lesions, about 17 cases (30.9 %) and (2). malignant lesions in about 38 cases (69.1 %).…”

Section: Resultsmentioning

confidence: 99%

“…The Ki67 protein has a half-life of only ~1-1.5 hours. It is present during all active phases of the cell cycle (G1, S, G2, and M), but is absent in resting cells (G0) (2,9). In later phases of mitosis (during anaphase and telophase), a sharp decrease in Ki67 levels occurs (10).…”

Section: Discussionmentioning

confidence: 99%

“…Prostatic intraepithelial neoplasia (PIN) increases the risk of prostate cancer. On transrectal ultrasound, the PIN may be hypoechoic, like carcinoma but this declaration had not been confirmed (1)(2)(3). Most urologists and radiologists do not believe that PIN can be detected by using transrectal ultrasound and magnetic resonance imaging (MRI) because the PIN is a microscopic finding (4).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cut-off Point of Ki-67 Proliferation Marker in Differentiating Premalignant and Malignant Prostatic Lesions

Laksmi¹,

Ilyas

Siregar

et al. 2022

Gac Méd Caracas

View full text Add to dashboard Cite

Immunohistochemistry Ki-67 is a marker of cell proliferation. Using immunohistochemical markers can be helpful to determine and diagnose prostate intraepithelial neoplasia (PIN) and carcinoma prostate. There are many studies about Ki67 as a prognostic tool, a diagnostic tool, and a potential therapeutic target for cancer therapy, but there are no standard criteria to define the cut-off point for the value of Ki-67 in premalignant and malignant prostate lesions.

show abstract

“…We divided them into two types of lesions: (1). premalignant lesions, about 17 cases (30.9 %) and (2). malignant lesions in about 38 cases (69.1 %).…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cut-off Point of Ki-67 Proliferation Marker in Differentiating Premalignant and Malignant Prostatic Lesions

Laksmi¹,

Ilyas

Siregar

et al. 2022

Gac Méd Caracas

View full text Add to dashboard Cite

show abstract

“…On TRUS, prostate carcinoma is most often hypoechoic relative to the normal peripheral zone but may sometimes be isoechoic or even hyperechoic. Asymmetry in prostate size, particularly in the peripheral zone, capsular distortion, and loss of differentiation between the central gland and the peripheral zone may also be seen [20,21].…”

Section: Discussionmentioning

confidence: 99%

Transrectal ultrasound in patients with hematospermia

Razek

Elhanbly

Eldeak

2010

Journal of Ultrasound

View full text Add to dashboard Cite

KEYWORDSHematospermia; Ultrasound; Prostatitis.Abstract Introduction: To illustrate the lesions detected with transrectal ultrasound (TRUS) in patients with hematospermia. Material and methods: This study included 74 male patients (25e73 years old) affected by hematospermia. Clinical history was obtained and all patients underwent rectal examination as well as TRUS examination in both axial and coronal planes to evaluate the prostate, ejaculatory ducts and seminal vesicles. Biopsy was performed in 10 patients. Results: Abnormalities were detected in 59 patients. Calculi (n Z 20) were seen within the prostate, seminal vesicles and along the course of the ejaculatory ducts. Chronic prostatitis (n Z 14) appeared as hyperechoic and hypoechoic areas within the prostate with capsule thickening suggesting seminal vesiculitis (n Z 8). Granulomatous prostatitis (n Z 3) appeared as hyperechoic and calcified areas scattered within the prostate and the seminal vesicles. Hypoechoic focal lesions and heterogeneous texture were seen in prostate cancer (n Z 5). Utricular cysts (n Z 3) appeared as small midline lesions, and Mullerian duct cysts (n Z 8) appeared as larger midline cysts protruding above the prostate. Ejaculatory duct cysts (n Z 4) appeared as thick walled cystic lesions along the course of the ejaculatory duct. Seminal vesicle cysts were detected in 2 patients. Conclusion: Our conclusion is that TRUS is a safe, non-invasive technique which can be used to detect lesions of the prostate, seminal vesicles and the ejaculatory ducts in patients with hematospermia.Sommario Introduzione: Illustrare le lesioni identificate con ecografia prostatica transrettale in pazienti con ematospermia. Materiali e metodi: Il presente studio include 74 pazienti di sesso maschile (25e73 anni) con ematospermia. Tutti i pazienti successivamente sono stati sottoposti a esame ecografico prostatico transrettale sui piani assiale e coronale della prostata, dei dotti eiaculatori e delle vescichette seminali dopo aver effettuato l'anamnesi e l'esplorazione rettale. La biopsia è stata effettuata in 10 pazienti. Risultati: In 59 pazienti sono stati identificati reperti patologici. Calcoli (n Z 20) sono stati identificati entro il parenchima ghiandolare prostatico, nelle vescichette seminali e lungo il decorso dei dotti eiaculatori. La prostatite cronica (n Z 14) si presentava con un'immagine iperecogena con aree ipoecogene del parenchima ghiandolare con ispessimento della capsula che si associava con vesciculite seminale (n Z 8). La prostatite granulomatosa (n Z 3) appariva iperecogena con alcune regioni calcifiche distribuite nella prostata e nelle vescichette seminali. Nei casi di tumore della prostata sono stati identificate lesioni focali ipoecogene e ecostruttura eterogenea (n Z 5). La cisti utriculare (n Z 3) era una lesione della linea mediana e le cisti dei Dotti Mulleriani (n Z 8) apparivano come una cisti della linea centrale più grande che protrudeva sopra la prostata. Le cisti dei dotti eiaculatori (n Z 4) apparivano come lesioni con ...

show abstract

“…Prostatic intraepithelial neoplasia (PIN), especially high-grade PIN, is accepted as a premalignant lesion and as a precursor of prostate cancer. Moreover, even though PIN and prostate cancer foci have reportedly been shown to have similar appearances as depicted on TRUS, clusters of millimetric hypoechoic foci may indicate high-grade PIN foci (15). Our results support findings of previous reports in terms of the significance of clusters; clusters were found in 29% of malignant lesions and in 9% of benign lesions ( p < 0.001).…”

Section: Discussionmentioning

confidence: 99%

Classification of Focal Prostatic Lesions on Transrectal Ultrasound (TRUS) and the Accuracy of TRUS to Diagnose Prostate Cancer

Lee

Byun

et al. 2009

Korean J Radiol

View full text Add to dashboard Cite

ObjectiveTo improve the diagnostic efficacy of transrectal ultrasound (TRUS)-guided targeted prostatic biopsies, we have suggested the use of a new scoring system for the prediction of malignancies regarding the characteristics of focal suspicious lesions as depicted on TRUS.Materials and MethodsA total of 350 consecutive patients with or without prostate cancer who underwent targeted biopsies for 358 lesions were included in the study. The data obtained from participants were randomized into two groups; the training set (n = 240) and the test set (n = 118). The characteristics of focal suspicious lesions were evaluated for the training set and the correlation between TRUS findings and the presence of a malignancy was analyzed. Multiple logistic regression analysis was used to identify variables capable of predicting prostatic cancer. A scoring system that used a 5-point scale for better malignancy prediction was determined from the training set. Positive predictive values for malignancy prediction and the diagnostic accuracy of the scored components with the use of receiver operating characteristic curve analysis were evaluated by test set analyses.ResultsSubsequent multiple logistic regression analysis determined that shape, margin irregularity, and vascularity were factors significantly and independently associated with the presence of a malignancy. Based on the use of the scoring system for malignancy prediction derived from the significant TRUS findings and the interactions of characteristics, a positive predictive value of 80% was achieved for a score of 4 when applied to the test set. The area under the receiver operating characteristic curve (AUC) for the overall lesion score was 0.81.ConclusionWe have demonstrated that a scoring system for malignancy prediction developed for the characteristics of focal suspicious lesions as depicted on TRUS can help predict the outcome of TRUS-guided biopsies.

show abstract

Transrectal sonographic features of prostatic intraepithelial neoplasia: Correlation with pathologic findings

Abstract: TRUS-detected CMHF may indicate HGPIN. Because of the limited sensitivity of this finding, TRUS detection of CMHF does not warrant biopsy, although these lesions warrant close monitoring.

Cited by 7 publications

References 20 publications

Cut-off Point of Ki-67 Proliferation Marker in Differentiating Premalignant and Malignant Prostatic Lesions

Cut-off Point of Ki-67 Proliferation Marker in Differentiating Premalignant and Malignant Prostatic Lesions

Transrectal ultrasound in patients with hematospermia

Classification of Focal Prostatic Lesions on Transrectal Ultrasound (TRUS) and the Accuracy of TRUS to Diagnose Prostate Cancer

Contact Info

Product

Resources

About