Transplantation tolerance by 1,25-dihydroxyvitamin D3-induced costimulation blockade

Gregori, Silvia; Casorati, Mara; Amuchastegui, Susanna; Smiroldo, Simona; Davalli, Alberto M.; Adorini, Luciano

doi:10.1016/s0041-1345(00)01981-3

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…Mice with functioning grafts for over 70 days after transplantation were injected intraperitoneally with donor spleen cells to look at transplantation tolerance. Interestingly, MMF and calcitriol combination therapy resulted in significantly higher resistance to islet graft rejection, compared to MMF or calcitriol monotherapy [82]. In another study [83], the same authors demonstrated that a short-term treatment with MMF and calcitriol resulted in induction of tolerance to islet allografts in STZ-induced diabetic recipient mice.…”

Section: Allogeneic Islet Transplantationmentioning

confidence: 98%

“…Some studies investigated the effects of vitamin D and its analogs in animal models of allogeneic islet transplantation to assess whether they may prevent allograft rejection and/or prolong allograft survival. Gregori et al [82] showed that a 30-day calcitriol and mycophenolate mofetil (MMF) treatment of STZ-induced diabetic mice, transplanted with allogeneic islets, significantly prolonged islet graft survival compared to mice treated with calcitriol or MMF alone. Mice with functioning grafts for over 70 days after transplantation were injected intraperitoneally with donor spleen cells to look at transplantation tolerance.…”

Section: Allogeneic Islet Transplantationmentioning

confidence: 99%

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The Role of Vitamin D and Omega-3 PUFAs in Islet Transplantation

et al. 2019

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Recurrence of autoimmunity and allograft rejection represent major challenges that impact the success of islet transplantation. Despite the remarkable improvements achieved in immunosuppression strategies after the publication of the Edmonton protocol, long-term data of intra-hepatic islet transplantation show a gradual decline in beta-cell function. Therefore, there is a growing interest in the investigation of novel, safe and effective anti-inflammatory and immunomodulatory strategies able to promote long-term islet graft survival and notable improvements in clinical outcomes of islet transplant recipients. Vitamin D has been shown to exert anti-inflammatory and immunomodulatory effects. Pre-clinical studies investigating the use of vitamin D and its analogs (alone or in combination with immunosuppressive agents and/or other anti-inflammatory agents, such as omega-3 polyunsaturated fatty acids) showed beneficial results in terms of islet graft survival and prevention of recurrence of autoimmunity/allograft rejection in animal models of syngeneic and allogeneic islet transplantation. Moreover, epidemiologic studies demonstrated that vitamin D deficiency is highly prevalent after solid organ transplantation (e.g., heart, liver or kidney transplantation). However, studies that critically assess the prevalence of vitamin D deficiency among islet transplant recipients have yet to be conducted. In addition, prospective studies aimed to address the safety and efficacy of vitamin D supplementation as an adjuvant immunomodulatory strategy in islet transplant recipients are lacking and are therefore awaited in the future.

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Section: Allogeneic Islet Transplantationmentioning

confidence: 98%

Section: Allogeneic Islet Transplantationmentioning

confidence: 99%

The Role of Vitamin D and Omega-3 PUFAs in Islet Transplantation

et al. 2019

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“…Calcitriol provides innate immunity in humans against certain infectious diseases as it has immuno-modulatory activity which facilitates the proliferation of monocytes by activating them, where as suppresses immunoglobulin production, proliferation of lymphocytes and cytokine synthesis. This is crucial in the body's defense mechanism against TB, in which the attack of macrophages is a key step in pathogenesis [10][11][12] . S-25(OH)D carries out its action through binding to Vitamin D Receptor (VDR) [13] .…”

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confidence: 99%

Vitamin D status among Pulmonary Tuberculosis Drug Induced Hepatotoxicity of Anti-tubercular Therapy

Parasher¹

2017

jmscr

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“…In summary, these investigations show that 1,25‐dihydroxyvitamin D 3 exerts effects on Langerhans cells, that are characteristic of UV‐induced suppression of CHS. Additionally, it has been shown that other immunomodulatory effects that are characteristic for UVS, including induction of CD4 + CD25 + T regulatory cells [Kao et al, 2001; Gregori et al, 2002] and T regulatory 1 cells [Barrat et al, 2002; Schwarz, 2002], effects on T‐cell infiltration in various models of Th 1 mediated autoimmune diseases, and on cytokine profiles in skin cells, are mediated by 1,25‐dihydroxyvitamin D 3 [Adorini, 2000, 2002; Gregori et al, 2001a,b, 2002; Penna and Adorini, 2001; Mathieu and Adorini, 2002; Schwarz, 2002]. Furthermore, it has been demonstrated that 1,25‐dihydroxyvitamin D 3 has the capacity to inhibit costimulatory pathways for T‐cell activation [Penna and Adorini, 2001].…”

mentioning

confidence: 99%