Ultraviolet light (UV)‐induced immunosuppression: Is vitamin D the missing link?

Reichrath, Jörg; Rappl, Gunter

doi:10.1002/jcb.10516

Cited by 23 publications

(17 citation statements)

References 19 publications

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“…62 Indeed, it has been suggested that some, at least, of the immunosuppressive effects of sun exposure may be mediated by vitamin D production. 63 Therefore, more research is required before we can be at all certain that vitamin D synthesis mediates a protective effect of sun exposure against NHL, if there is one.…”

Section: Resultsmentioning

confidence: 99%

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Hughes

Armstrong

Vajdic

et al. 2004

Intl Journal of Cancer

139

103

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Section: Resultsmentioning

confidence: 99%

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Hughes

Armstrong

Vajdic

et al. 2004

Intl Journal of Cancer

139

103

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“…Recently, new and important immunomodulatory effects of vitamin D analogs have been characterized, especially those for 1,25(OH) 2 D3 [1], [25], [67]. Inhibitors targeting the NF-κB signaling pathway effectively suppress NF-κB activity, protect and relieve inflammatory symptoms, and induce apoptosis of tumor cells.…”

Section: Discussionmentioning

confidence: 99%

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

et al. 2009

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The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes. Since nuclear factor-κB (NF-κB) plays a pivotal role in the regulation of cell proliferation, differentiation and apoptosis, we examined the capability of 20-hydroxycholecalciferol to modulate the activity of NF-κB, using 1,25-dihydroxycholecalciferol (calcitriol) as a positive control. 20-hydroxycholecalciferol inhibits the activation of NFκB DNA binding activity as well as NF-κB-driven reporter gene activity in keratinocytes. Also, 20-hydroxycholecalciferol induced significant increases in the mRNA and protein levels of the NF-κB inhibitor protein, IκBα, in a time dependent manner, while no changes in total NF-κB-p65 mRNA or protein levels were observed. Another measure of NF-κB activity, p65 translocation from the cytoplasm into the nucleus was also inhibited in extracts of 20-hydroxycholecalciferol treated keratinocytes. Increased IκBα was concomitantly observed in cytosolic extracts of 20-hydroxycholecalciferol treated keratinocytes, as determined by immunoblotting and immunofluorescent staining. In keratinocytes lacking vitamin D receptor (VDR), 20-hydroxycholecalciferol did not affect IκBα mRNA levels, indicating that it requires VDR for its action on NF-κB activity. Comparison of the effects of calcitrol, hormonally active form of vitamin D3, with 20-hydrocholecalciferol show that both agents have a similar potency in inhibiting NF-κB. Since NF-κB is a major transcription factor for the induction of inflammatory mediators, our findings indicate that 20-hydroxycholecalciferol may be an effective therapeutic agent for inflammatory and hyperproliferative skin diseases.

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“…Immunosuppressive properties have been demonstrated for both UV-B and UV-A [17]. It has been hypothesized that UV-B-induced production of vitamin D may be involved in UV-B-induced immunosuppression [18]. During the last decades, public health campaigns have improved our knowledge regarding risk of UV-radiation for skin cancers.…”

Section: Solar Uv-exposure Skin Malignancies and Cancer Prevention Cmentioning

confidence: 99%

Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk groups?

Ultraviolet light (UV)‐induced immunosuppression: Is vitamin D the missing link?

Cited by 23 publications

References 19 publications

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

Sun exposure may protect against non‐Hodgkin lymphoma: A case‐control study

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

Sunlight, skin cancer and vitamin D: What are the conclusions of recent findings that protection against solar ultraviolet (UV) radiation causes 25-hydroxyvitamin D deficiency in solid organ-transplant recipients, xeroderma pigmentosum, and other risk groups?

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