Transplantable Human Tumors in Experimental Chemotherapy: Effects of Actinomycins on H.S. #1 and H.Ep. #3 in the Rat2

Teller, Morris N.; Merker, Philip C.; Palm, Joy; Woolley, George W.

doi:10.1093/jnci/28.2.353

Cited by 7 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UV spectra were recorded on either a Perkin-Elmer 124 or a Hewlett-Packard 8452A spectrophotometer in methanol or ethanol. 1 H and 13 C NMR spectra were recorded on either a Varian Gemini 300 or a Bruker Avance DPX 300 spectrometer using TMS as an internal standard in DMSO-d 6, CDCl3, or D2O. Mass spectra were recorded on either a Varian-MAT 311A (electron impact and fast atom bombardment) or a Micromass Platform LCZ (Electrospray).…”

Section: Methodsmentioning

confidence: 99%

“…Figure 2 shows 1 H NMR spectra of compounds 2i, 3i, and 4 from which it is evident that a monoalkylation reaction had taken place and that the reaction occurred at the quinolone part of the molecule. The structures of the novel compounds were determined on the basis of analysis of chemical shifts and H-H coupling constants in 1 H NMR spectra and 13 C NMR spectra as well as by elemental analysis.…”

Section: Chemistrymentioning

confidence: 99%

“…Few data have been publish describing the antitumor activity of heterocyclic condensed quinolones. The novel quinoline-quinone streptonigrin (SN) is an antitumor antibiotic that has activity against a broad range of tumors. − Although SN has been studied clinically as an antitumor agent, its use has been limited by reports of delayed myelotoxicity. , Nevertheless, positive results were reported for SN either as a single agent , or in combination chemotherapy. , SN is an excellent substrate for oxidoreductase (NQ01) …”

Section: Introductionmentioning

confidence: 99%

“…The novel quinoline-quinone streptonigrin (SN) is an antitumor antibiotic that has activity against a broad range of tumors. [12][13][14] Although SN has been studied clinically as an antitumor agent, its use has been limited by reports of delayed myelotoxicity. 15,16 Nevertheless, positive results were reported for SN either as a single agent 17,18 or in combination chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Novel Derivatives of Benzo[b]thieno[2,3-c]quinolones: Synthesis, Photochemical Synthesis, and Antitumor Evaluation

et al. 2003

View full text Add to dashboard Cite

Novel derivatives of benzo[b]thieno[2,3-c]quinolones 3a-j were synthesized in a multistep synthesis starting from substituted benzo[b]thiophene-2-carbonyl chlorides, to their corresponding benzo[b]thiophene-2-carboxamides, which were photochemically dehydrohalogenated to their corresponding substituted benzo[b]thieno[2,3-c]quinolones. Compound 4 was prepared from 3i by alkylation with 3-dimethylaminopropyl chloride in the presence of NaH. Compounds 7a,b were prepared from 3g in the multistep synthesis from compounds 5 and 6. Compounds 3b, 3c-f, 3h, 7a, and 7b were found to exert cytostatic activity against malignant cell lines: pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), cervical carcinoma (HeLa), laryngeal carcinoma (Hep2), colon carcinoma (CaCo-2), melanoma (HBL), human fibroblast cell lines (WI-38). The compounds that bear a 3-dimethylaminopropyl substituent on the quinolone nitrogen (3b, 3c-f, 3h) showed higher antitumor activity than compounds bearing the same substituent on the amidic nitrogen (7a and 7b). The compound 3h, which has a 3-dimethylaminopropyl substituent on the quinolone nitrogen and a methoxycarbonyl substituent at position 9, had marked antitumor activity. Because of strong cytotoxic effect of compound 4 on melanoma cells (HBL, ME 67.3, and ME 67.1), a potential mechanism of action was examined. Analysis of DNA and Annexin-V-FLUOS staining indicated that compound 4 causes cell death by apoptosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel Derivatives of Benzo[b]thieno[2,3-c]quinolones: Synthesis, Photochemical Synthesis, and Antitumor Evaluation

et al. 2003

View full text Add to dashboard Cite

show abstract

“…1 and HEp no. 3 in conditioned rats (11,19) and in Swiss mice (8) by streptonigrin also has been observed. Additionally, streptonigrin was found to possess antiviral activity against the Ruscher virus in mice (6).…”

mentioning

confidence: 72%

Biological Assay of Streptonigrin (NSC 45383) in Body Fluids and Tissues of Mice

Pittillo

Woolley

1974

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

Cytostatische Antibiotica

Schmidt¹

1963

Ergebnisse Der Inneren Medizin Und Kinderheilkunde

View full text Add to dashboard Cite

Transplantable Human Tumors in Experimental Chemotherapy: Effects of Actinomycins on H.S. #1 and H.Ep. #3 in the Rat2

Cited by 7 publications

References 0 publications

Novel Derivatives of Benzo[b]thieno[2,3-c]quinolones: Synthesis, Photochemical Synthesis, and Antitumor Evaluation

Novel Derivatives of Benzo[b]thieno[2,3-c]quinolones: Synthesis, Photochemical Synthesis, and Antitumor Evaluation

Biological Assay of Streptonigrin (NSC 45383) in Body Fluids and Tissues of Mice

Cytostatische Antibiotica

Contact Info

Product

Resources

About