Biological Assay of Streptonigrin (NSC 45383) in Body Fluids and Tissues of Mice

Pittillo, Robert F.; Woolley, Carolyn

doi:10.1128/aac.5.1.82

Cited by 3 publications

(1 citation statement)

References 10 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, it was found that, in some resistant cases, SN was effective where other chemotherapeutics had failed (36). Furthermore, in cases where toxic side effects were minimized, tumor regression and associated clinical benefits occurred in advanced cancer patients (57,58). Although an exact mechanism for how SN exerts its effect in vivo is unknown, it is proposed that the antitumor activity of SN can be attributed to its quinone group and its ability to generate ROS (59).…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Activities of RAD54, a SWI2/SNF2 Protein, Using a Specific Small-molecule Inhibitor

Deakyne

Huang

Negri

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: RAD54 performs branch migration and stimulation of RAD51 DNA strand exchange. Results: Streptonigrin inhibits branch migration through specific binding to RAD54 but spares stimulation of RAD51-mediated DNA strand exchange. Conclusion: RAD54 ATPase activity is relatively less important in the stimulation of DNA pairing than in branch migration. Significance: Small-molecule inhibitors are instrumental to study the mechanisms of RAD54 activities.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of the Activities of RAD54, a SWI2/SNF2 Protein, Using a Specific Small-molecule Inhibitor

Deakyne

Huang

Negri

et al. 2013

Journal of Biological Chemistry

View full text Add to dashboard Cite

show abstract

Streptonigrin

Mizuno¹

1979

Mechanism of Action of Antieukaryotic and Antiviral Compounds

View full text Add to dashboard Cite

NQO1-directed antitumour quinones

Alcaı́n

Villalba

2007

Expert Opinion on Therapeutic Patents

View full text Add to dashboard Cite

NAD(P)H:(quinone acceptor) oxidoreductase 1 (NQO1) is a cytosolic flavoenzyme that catalyses the obligatory two-electron reduction of several quinones to their corresponding hydroquinones by using both NADH and NADPH. NQO1 has relevance in chemotherapy because bioreductive drugs require enzymatic activation prior to conversion into cytotoxic compounds. Because levels of NQO1 are elevated in some tumours, the enzyme provides an opportunity to develop improved new chemotherapeutic drugs that are bioactivated by this enzyme. The classical NQO1-directed drugs are quinone-containing alkylating agents, such as the prototypical bioreductive agent mitomycin C, and different azirinidylbenzoquinones, such as 2,5 bis-[1-aziridyl]-1,4 benzoquinone, that target DNA crosslinks and strand breaks after reduction. New analogues of those quinones, such as EO9 and RH1, have been developed to overcome the poor substrate specificity and poor solubility in aqueous solution in order to improve its therapeutic utilisation. Also, NQO1 is implied in the activation of new drugs that act as inhibitors of different proteins. β-Lapachone is not a DNA damaging agent and preclinical studies have shown very promising results. The benzoquinone ansamycins, 17-allylamino,17-demethoxygeldanamycin and 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin, which exhibit anticancer activity by binding to heat-shock protein 90 (Hsp90), are also in clinical trials. NQO1 activity needs a threshold value to induce cytotoxicity. As a polymorphism in NQO1, known as NQO1*2, results in dramatically decreased NQO1 enzyme activity, NQO1 polymorphism should be carefully monitored in the patients before the use of NQO1-directed drugs.

show abstract

Biological Assay of Streptonigrin (NSC 45383) in Body Fluids and Tissues of Mice

Cited by 3 publications

References 10 publications

Analysis of the Activities of RAD54, a SWI2/SNF2 Protein, Using a Specific Small-molecule Inhibitor

Analysis of the Activities of RAD54, a SWI2/SNF2 Protein, Using a Specific Small-molecule Inhibitor

Streptonigrin

NQO1-directed antitumour quinones

Contact Info

Product

Resources

About