Streptonigrin

Mizuno, N.

doi:10.1007/978-3-642-46407-2_19

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“…Most synthetic compounds containing the 5,8-quinolinedione scaffold exhibit better activity and lower toxicity than natural antibiotics 1 – 3 [17,29,30]. This review presents selected examples of synthetic derivatives of 5,8-quinolinedione and their biological activity.…”

Section: Introductionmentioning

confidence: 99%

5,8-Quinolinedione Scaffold as a Promising Moiety of Bioactive Agents

et al. 2019

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Natural 5,8-quinolinedione antibiotics exhibit a broad spectrum of activities including anticancer, antibacterial, antifungal, and antimalarial activities. The structure–activity research showed that the 5,8-quinolinedione scaffold is responsible for its biological effect. The subject of this review report is a presentation of the pharmacological activity of synthetic 5,8-quinolinedione compounds containing different groups at C-6 and/or C-7 positions. The relationship between the activity and the mechanism of action is included if these data have been included in the original literature. The review mostly covers the period between 2000 and 2019. Previously published literature data were used to present historical points.

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Section: Introductionmentioning

confidence: 99%