A microbiological assay was developed for bleomycin, an antitumor antibiotic reported to be active in human trials. The assay bacterium was a strain of
Escherichia coli
which is resistant to ethionine. Studies revealed relatively high concentrations of bleomycin in the blood and urine of mice after a single dose, < 0.33
ld
10
, injected intraperitoneally.
A 6-chloropurine-resistant strain of
Escherichia coli
has been used to develop a microbiological assay for the estimation of 5-azacytidine distribution in mouse tissues.
A microbiological assay for pseudourea, 2,2′-(9,10-anthrylenedimethylene)bis-(2-thio-, dihydrochloride) dihydrate (NSC 56054), a new anticancer agent, has been developed and tissue distribution studies in mice have been performed.
A microbiological assay for pseudourea, 2,2'-(9,10-anthrylenedimethylene)bis-(2-thio-, dihydrochloride) dihydrate (NSC 56054), a new anticancer agent, has been developed and tissue distribution studies in mice have been performed.
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