Pseudourea, 2,2′-(9,10-Anthrylenedimethylene) bis-(2-thio-, dihydrochloride) Dihydrate: Microbiological Assay and Tissue Distribution Studies in Mice1

Abstract

A microbiological assay for pseudourea, 2,2'-(9,10-anthrylenedimethylene)bis-(2-thio-, dihydrochloride) dihydrate (NSC 56054), a new anticancer agent, has been developed and tissue distribution studies in mice have been performed.

Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand

“…Anthracene derivatives have been investigated for their binding to DNA, and some are promising chemotherapeutic agents [142,143]. Anthracene itself has been reported to be effective against psoriasis [144]; while other anthracene derivatives tested for their anti-cancer activity include mitoxantrone, ametantrone, and bisantrene [145][146][147]. Mitoxantrone, ametantrone, and bisantrene have been suggested to elicit their activity by binding to DNA through groove/electrostatic as well as intercalative binding modes [145][146][147].…”