Transmission line matrix modelling of thermal injuries to skin

Bellia, S. Aliouat; Saïdane, A.; Hamou, A.; Benzohra, M.; Saiter, Jean Marc

doi:10.1016/j.burns.2007.09.003

Cited by 11 publications

(4 citation statements)

References 35 publications

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“…While there are conceivable situations in which patients may tolerate (or acclimate to) higher temperatures for extended periods, this maximum tolerated temperature of 42–43°C may appropriately represent the worst-case scenario for TDS exposure to an elevated temperature. This maximum tolerable temperature value is also supported by observations reported in the literature (9,22,23). Together, the results in the present study suggest a baseline skin temperature range of 32–33°C and an upper skin temperature range of 42–43°C to evaluate heat effects on transdermal delivery in Franz diffusion cell experiments in vitro .…”

Section: Resultssupporting

confidence: 91%

Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

et al. 2017

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Purpose Performance of a transdermal delivery system (TDS) can be affected by exposure to elevated temperature, which can lead to unintended safety issues. This study investigated TDS and skin temperatures and their relationship in vivo, characterized the effective thermal resistance of skin, and identified the in vitro diffusion cell conditions that would correlate with in vivo observations. Methods Experiments were performed in humans and in Franz diffusion cells with human cadaver skin to record skin and TDS temperatures at room temperature and with exposure to a heat flux. Skin temperatures were regulated with two methods: a heating lamp in vivo and in vitro, or thermostatic control of the receiver chamber in vitro. Results In vivo basal skin temperatures beneath TDS at different anatomical sites were not statistically different. The maximum tolerable skin surface temperature was approximately 42–43°C in vivo. The temperature difference between skin surface and TDS surface increased with increasing temperature, or with increasing TDS thermal resistance in vivo and in vitro. Conclusions Based on the effective thermal resistance of skin in vivo and in vitro, the heating lamp method is an adequate in vitro method. However, the in vitro-in vivo correlation of temperature could be affected by the thermal boundary layer in the receiver chamber.

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Section: Resultssupporting

confidence: 91%

Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

et al. 2017

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“…They reported that the epidermis and dermis thicknesses significantly affect the temperature and burn injury distributions – the thicker the epidermis and dermis, the less the thermal damage. Consistent results are also reported by Aliouat Bellia et al [132]. Ng et al [125] performed a parametric and sensitivity analysis on how different thermal properties of skin affected the level of burn injuries.…”

Section: Part 2: Numerical Studiessupporting

confidence: 79%

Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models

2017

Burns

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Thermal injury to skin and subcutaneous tissue is common in both civilian and combat scenarios. Understanding the change in tissue morphologies and properties and the underlying mechanisms of thermal injury are of vital importance to clinical determination of the degree of burn and treatment approach. This review aims at summarizing the research involving experimental and numerical studies of skin and subcutaneous tissue subjected to thermal injury. The review consists of two parts. The first part deals with experimental studies including burn protocols and prevailing imaging approaches. The second part deals with existing numerical models for burn injuries of tissue and related computational simulations. Based on this review, we conclude that though there is literature contributing to the knowledge of the pathology and pathogenesis of tissue burn, there is scant quantitative information regarding changes in tissue properties including mechanical, thermal, electrical and optical properties as a result of burn injuries that are linked to altered tissue morphology.

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“…The unit time Δt is then the time required for a wave field to travel from one node to the next. TLM method was used in a wide range of propagation and diffusion problems; starting by electromagnetics, acoustics and computational mechanics [43][44][45] to extend after at the biomedical treatments especially with high temperatures [31,[46][47][48][49]. However, investigation of the temperature field in cryotherapy treatments with non-isothermal phase change is not yet established by the TLM model.…”

Section: Numerical Model Setupmentioning

confidence: 99%

“…The TLM routine operates on travelling, scattering and connecting of voltage (temperature) pulses between the network nodes. In the interest of brevity, details on the TLM routine, which are described in several papers [31,46,47,49], will not be covered in this study.…”

Section: Numerical Model Setupmentioning

confidence: 99%

A TLM study of bioheat transfer during freeze-thaw cryosurgery

Bellil

Saïdane

Bennaoum

2018

Biomed. Phys. Eng. Express

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The transmission line matrix (TLM) method is developed to efficiently solve the bioheat transfer with phase change in freeze-thaw cryoablation. This new design of three dimensional TLM model with an automatic time stepping is based on hyperbolic heat transfer model. It is able to consider many factors such as temperature-dependant thermophysical properties during phase change, blood perfusion and latent heat release/absorption. Thermal analysis of heat transfer in the cryotreated tissue is detailed; with special emphases on lethal temperature isotherms with respect to the cooling rates and duration of freeze-thaw cycle. The basic numerical model is validated through available experimental data on skeletal muscle of rabbit hind-limbs. Nomenclature c Volumetric specific heat (J/m 3 °. C) L Latent heat l Liquid phase ls Liquid-solid phase m Metabolic heat p Perfusion s Solid phase RECEIVED

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Transmission line matrix modelling of thermal injuries to skin

Cited by 11 publications

References 35 publications

Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

Characterization of Temperature Profiles in Skin and Transdermal Delivery System When Exposed to Temperature Gradients In Vivo and In Vitro

Thermal injury of skin and subcutaneous tissues: A review of experimental approaches and numerical models

A TLM study of bioheat transfer during freeze-thaw cryosurgery

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