1982
DOI: 10.1016/0165-4608(82)90103-0
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Translocations involving chromosomes #3 and #12: Hematologic diseases associated with abnormalities of these chromosomes

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Cited by 28 publications
(3 citation statements)
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“…It may be of some relevance, however, that the p21 c-Ki-ras2 oncogene has been mapped to 12 [39]. Chromosomes 4 and 12 are not selectively altered in ALL but there is a striking, nonrandom occurrence of trisomy 12 in several B cell malignancies including B chronic lymphocytic leukemia [40], non Hodgkin lymphoma 1411 and hairy cell leukemia [42].…”
Section: Discussionmentioning
confidence: 94%
“…It may be of some relevance, however, that the p21 c-Ki-ras2 oncogene has been mapped to 12 [39]. Chromosomes 4 and 12 are not selectively altered in ALL but there is a striking, nonrandom occurrence of trisomy 12 in several B cell malignancies including B chronic lymphocytic leukemia [40], non Hodgkin lymphoma 1411 and hairy cell leukemia [42].…”
Section: Discussionmentioning
confidence: 94%
“…The sites to which we have mapped c-ras-related sequences are involved in gain, loss, deletion, duplication, and translocation (with breakpoints in lipl4, 12pll, 12q24, and 3p2l) in a number of myeloid and lymphoid neoplasms (9,37,38). An inherited translocation, t(3;8) (p21;q24), has been reported to be associated with hereditary renal cell carcinoma in one family (39).…”
Section: Discussionmentioning
confidence: 99%
“…The initial finding of this chromosomal abnormality in the cells of small cell lung cancer was certainly exciting, but more recently this region of chromosome 3 has become even more important because it appears to be altered in other malignancies, such as renal cell carcinoma, 6 cancer of the ovary, 7 salivary gland tumors, 8 and leukemia. 9 The short arm of chromosome 3 may literally be a genetic hot spot for cancer ( Fig. 2).…”
Section: Chromosomes and Cancermentioning
confidence: 99%