Translocations involving chromosomes #3 and #12: Hematologic diseases associated with abnormalities of these chromosomes

Sandberg, Avery A.; Hecht, Barbara K.; Ondreyco, Sharon M.; Prieto, Félix; Hecht, Frederick

doi:10.1016/0165-4608(82)90103-0

Cited by 28 publications

(3 citation statements)

References 80 publications

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“…It may be of some relevance, however, that the p21 c-Ki-ras2 oncogene has been mapped to 12 [39]. Chromosomes 4 and 12 are not selectively altered in ALL but there is a striking, nonrandom occurrence of trisomy 12 in several B cell malignancies including B chronic lymphocytic leukemia [40], non Hodgkin lymphoma 1411 and hairy cell leukemia [42].…”

Section: Discussionmentioning

confidence: 94%

Chromosome assignment of monoclonal antibody‐defined determinants on human leukemic cells

et al. 1983

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Hybrids formed between human acute lymphoblastic leukemia (ALL) cells and mouse myeloma have been used to determine the chromosomal location of genes required for the expression of several monoclonal antibody (mAb)-defined cell surface antigens on ALL cells. Cloned hybrids were tested for antibody binding, immunoprecipitation of the relevant protein, chromosome isoenzyme markers and karyotype. Two antigens of those studies could be definitively mapped, OKT10/p45 to chromosome 4 and BA-2/p24 to chromosome 12. mAb BA-2 reacts with the same protein as another mAb designated 609-29 (anti-teratocarcinoma). Reactivity with the latter mAb has been previously shown to segregate with chromosome 12.

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Section: Discussionmentioning

confidence: 94%

Chromosome assignment of monoclonal antibody‐defined determinants on human leukemic cells

et al. 1983

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“…The sites to which we have mapped c-ras-related sequences are involved in gain, loss, deletion, duplication, and translocation (with breakpoints in lipl4, 12pll, 12q24, and 3p2l) in a number of myeloid and lymphoid neoplasms (9,37,38). An inherited translocation, t(3;8) (p21;q24), has been reported to be associated with hereditary renal cell carcinoma in one family (39).…”

Section: Discussionmentioning

confidence: 99%

Localization of c-ras oncogene family on human germ-line chromosomes.

Jhanwar¹,

Neel²,

Hayward³

et al. 1983

Proc. Natl. Acad. Sci. U.S.A.

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The c-ras family is a set of c-onc genes that are highly conserved in vertebrates. The genes in this family are homologous to the transforming genes of Harvey and Kirsten murine sarcoma viruses (v-Ha-ras and v-Ki-ras, respectively). Using an in situ molecular hybridization method, we detected three sites on the human pachytene chromosomes that exhibited significant hybridization to v-Ki-ras and v-Ha-ras probes. These were chromomere positions that corresponded to bands lIpl4

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“…The initial finding of this chromosomal abnormality in the cells of small cell lung cancer was certainly exciting, but more recently this region of chromosome 3 has become even more important because it appears to be altered in other malignancies, such as renal cell carcinoma, 6 cancer of the ovary, 7 salivary gland tumors, 8 and leukemia. 9 The short arm of chromosome 3 may literally be a genetic hot spot for cancer ( Fig. 2).…”

Section: Chromosomes and Cancermentioning

confidence: 99%