Molecular Basis of Lung Cancer

Formation of dna adducts and water‐soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled

“…In view of the unequivocal importance of exogenous factors in lung carcinogenesis, the genetic predisposition can be explained by inherited factors modulating individual susceptibility to carcinogens (Strong, 1977;Nebert, 1978;Mulvihill, 1978;Miller, 1980). Attempts were made to relate isozymes and DNA polymorphisms to a genetic predisposition (Seidegard et al, 1986;Heighway et al, 1986;Gerber and Scoggin, 1986;Iannuzzi and Miller, 1986). Since most environmental carcinogens undergo metabolic activation or inactivation by genetically controlled enzyme systems, the determination of the activity and inducibility of the enzymes involved is a logical experimental approach for an individual risk assessment.…”