Transitional Nanoemulsification Methods

Anton, Nicolas; Akram, Salman; Vandamme, Thierry F.

doi:10.1016/b978-0-12-811838-2.00004-7

Cited by 11 publications

(10 citation statements)

References 54 publications

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“…Nonionic surfactants are used in the preparation of nanoemulsions and the literature has extensively shown their crucial role in the emulsification processes (N. Anton, Akram, & Vandamme, 2018;N. Anton & Vandamme, 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Both Jeffamine® polyetheramines (J-1000 and J-2000) used in this study are predominantly composed of PEG, making their structure highly similar to the polar head of nonionic surfactants generally used in the spontaneous nano-emulsification processes (N. Anton et al, 2018), and therefore should induce, similarly, efficient stabilizer properties of the species synthetized in the present study. In the case of nonionic surfactants, right after mixing, the water phase immediately and suddenly penetrate the oily phase to solubilize the amphiphilic molecules.…”

Section: Resultsmentioning

confidence: 99%

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Spontaneous nano-emulsification with tailor-made amphiphilic polymers and related monomers

Rehman

Collot

Klymchenko

et al. 2019

Eur. J. Pharm. Res.

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In general, nano-emulsions are submicron droplets composed of liquid oil phase dispersed in liquid aqueous bulk phase. They are stable and very powerful systems when it regards the encapsulation of lipophilic compounds and their dispersion in aqueous medium. On the other hand, when the properties of the nano-emulsions aim to be modified, e.g. for changing their surface properties, decorating the droplets with targeting ligands, or modifying the surface charge, the dynamic liquid / liquid interfaces make it relatively challenging. In this study, we have explored the development of nano-emulsions which were not anymore stabilized with a classical low-molecular weight surfactant, but instead, with an amphiphilic polymer based on poly(maleic anhydride-alt-1-octadecene) (PMAO) and Jeffamine®, a hydrophilic amino-terminated PPG/PEG copolymer. Using a polymer as stabilizer is a potential solution for the nano-emulsion functionalization, ensuring the droplet stabilization as well as being a platform for the droplet decoration with ligands (for instance after addition of function groups in the terminations of the chains). The main idea of the present work was to understand if the spontaneous emulsification –commonly performed with nonionic surfactants– can be transposed with amphiphilic polymers, and a secondary objective was to identify the main parameters impacting on the process. PMAO was modified with two different Jeffamine®, additionally different oils and different formulation conditions were evaluated. As a control, the parent monomer, octadecyl succinic anhydride (OSA) was also modified and studied in the similar way as that of polymer. The generated nano-emulsions were mainly studied by dynamic light scattering and electron microscopy, that allows discriminating the crucial parameters in the spontaneous process, originally conducted with polymers as only stabilizer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Spontaneous nano-emulsification with tailor-made amphiphilic polymers and related monomers

Rehman

Collot

Klymchenko

et al. 2019

Eur. J. Pharm. Res.

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“…It is generally recognized the cream are a formulation with high water content [6]. In prepared creams, percentages of water content started from 49.30 to 59.30 %w/w.…”

Section: Centrifugation Testmentioning

confidence: 99%

Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract

2020

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The herb extract of Euphorbia hirta L. have been reported as sources of inexpensive antioxidant that can be used as potential cosmetic product. Therefore, the aims of this study were to formulate E. hirta L. extract loaded cream and to assess the antioxidant activity of loaded cream. First, E. hirta L. was prepared with maceration process using water as solvent (1:5). Afterwards, the obtained extract was subjected to a lyophilisation process. The extract was tasted for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) for suitable concentration of the extract incorporated into the cream, which was 10%w/w. The cream was formulated as o/w emulsion and stearic acid was selected as an emulsifier. The extract loaded cream was tested pH, viscosity, and antioxidant. The freshly prepared extract loaded cream was dark green and no phase separation was observed after centrifugation at 3,000 rpm for 30 min. They had acidic pH (4.4-5.1), considered acceptable for skin application, especially in skin face. The DPPH measurement revealed that the formulation had potential antioxidant activity with %SCV more than 80% at 100 µg/mL. In conclusion, topical o/w cream containing extract was successfully prepared with substantial antioxidant activity and was displayed a potential use in cosmetic formulations, especially antiaging products.

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“…It is generally recognized that lotions are formulations with high water content (Anton, Akram, & Vandamme, 2018). In the prepared lotions, percentages of water content started from 44.80 to 48.80 %w/w.…”

Section: Characterization Of Emulsion Typementioning

confidence: 99%

FORMULATION AND INVESTIGATION OF ANTIOXIDANT POTENTIAL OF O/W LOTIONS CONTAINING Tamarindus indica L. FRUIT PULP EXTRACT

Isnaini

Songkro

Kaewnopparat

et al. 2019

mijst

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The fruit pulp extracts of Tamarindus indica have been reported to possess several biological activities, especially antioxidant property which is suitable for cosmetic application. Therefore, the aims of this study were to formulate the tamarind fruit pulp extract loaded lotions (o/w emulsions), and to assess the antioxidant activity of tamarind fruit pulp extract loaded lotions.Initially, tamarind fruit pulp extracts were prepared by a solvent extraction method. The solvents used were water or a mixture of water and ethanol (water: ethanol= 1:1). Afterwards, the obtained tamarind fruit pulp extracts were subjected to lyophilization process. The tamarind fruit pulp extracts were tested for antioxidant activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay to determine suitable concentrations of the extracts to be incorporated into the lotions, which were 2 and 4%w/w in the current study. Apart from the basic ingredients of the oil phase and water phase, ViscOptima SE (2%w/w) was selected as an emulsifier and a thickener of the formulations.The tamarind fruit pulp extract loaded lotions were characterized for physicochemical property and antioxidant potential. The freshly prepared tamarind fruit pulp extract loaded lotions were light brown with homogeneity and no phase separation was observed after centrifugation at 3,000 rpm for 30 min. They had weak acidic pH (4.4-5.1), considered acceptable for skin application.The loaded formulations (F1, 2%w/w) and F2, 4%w/w)) exhibited significantly higher conductivity values than that of the unloaded formulation (F0) (p<0.05). The formulations behaved as pseudoplastic flows with low viscosity. The DPPH measurement revealed that the formulations F1 and F2 had potential antioxidant activity. In conclusion, topical o/w lotions containing tamarind fruit pulp extract were successfully prepared. They had substantial antioxidant activities. As a result, tamarind fruit pulp extract loaded lotions displayed a potential use in cosmetic formulations, especially antiaging products.

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Transitional Nanoemulsification Methods

Cited by 11 publications

References 54 publications

Spontaneous nano-emulsification with tailor-made amphiphilic polymers and related monomers

Spontaneous nano-emulsification with tailor-made amphiphilic polymers and related monomers

Formulation and Investigation Antioxidant of O/W Cream Containing Euphorbia hirta L. Herb Extract

FORMULATION AND INVESTIGATION OF ANTIOXIDANT POTENTIAL OF O/W LOTIONS CONTAINING Tamarindus indica L. FRUIT PULP EXTRACT

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