Transition metal complexes with thiosemicarbazide-based ligands. XLIV. The supramolecular arrangement in the Ni(II) complexes of S-methylisothiosemicarbazide

Novaković, Sladjana B.; Bogdanović, Goran A.; Leovac, Vukadin M.

doi:10.1016/j.inoche.2004.10.001

Cited by 26 publications

(4 citation statements)

References 13 publications

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“…The IR spectrum of compound I shows bands at 3306, 3196, and 3092 cm −1 for the free-NH groups present in the ligand. The bands occurring at 1651, 1402, 1342, 902 and 831 cm −1 are assigned to ν(C=O), thioamide I [β(NH) + ν(CN)], thioamide II [ν(CN) + β(NH)], ν(N-N) and ν(C=S), respectively [22]- [27]. The assignments of the infrared bands, Table 1, were performed by comparing the spectra of the complexes with the free ligands.…”

Section: Infrared Spectra Of H 4 Oxtsc (I) and Its Metal Complexesmentioning

confidence: 99%

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Amin¹,

Elreedy²,

Alansi³

et al. 2016

OJIC

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The thermogravimetry (TG) and derivative thermogravimetry (DTG) have been used to study the thermal decomposition of some oxalyl (H 4 OxTSC), malonyl (H 4 MaTSC) and succinyl-bis-4-phenylthiosemicarbazide (H 4 SuTSC) ligands and their metal complexes using Horowitz-Metzger (HM) and Coats-Redfern methods. The kinetic thermodynamic parameters such as: E*, ΔH*, ΔS*and ΔG* are calculated from the DTG curves. The isolated complexes have the general composition [M 2 (L) (H 2 O) 6 ], where M=Cu(II), Zn(II), L=MaTSC and M=Co(II), Cu(II) or Sn(II) and L=Su TSC and [M 2 (L) (H 2 O) n ]·nH 2 O where M=Cu(II), Co(II) or Sn(II), L=OxTS or Ma TSC. The tested compounds show a good activity against four strains of bacteria Gram negative Escherichia coli, Pseudomonas aeruginosa species and gram-positive Bacillus cereus and Staphylococcus aureus.Keywords Metal (II) Complexes, Bis-Thiosemicarbazide, Thermogravimetric, Antibacterial Studies 1. Introduction Thiosemicarbazide and its derivatives have received considerable attention because of their pharamacological * Corresponding author.R. R. Amin et al. 90 properties [1]. Thiosemicarbazide complexes show a broad spectrum of anticancer activity [2] [3]. Also, thiosemicarbazide derivatives are of current interest with respect to their uses as analytical reagents for separations of metal(II) ions [4]-[7], analytical determination of metal ions [8] [9], and clinical analysis [10]. Most of these compounds have antifungal [11]-[12], antimicrobial [13] and antitumor activity [14]-[16], as well as radiopharmaceuticals applications [17]. Continuing our studies for the chemical and electrochemical synthesis of new metal complexes of ligands containing N, S and O atoms through the reaction of metal ions scarified from the anodic dissolution of metals [18] [19]. Our aim work in this paper to report novel complexes prepared from the reaction between bisthiosemicarbazi decompounds which have a good ability to form chelate complexes with transition metal [18]- [20]. We report here the thermal, spectral and biological evaluations of Co(II), Cu(II), Zn(II) and Sn(II) complexes for 1,1-oxalyl, malonyl and succinyl-bis-4-phenylthiosemicarbazide ligands. The modern spectroscopic investigations are used to elucidate the structure of the prepared materials. The thermal decomposition is also used to infer the structure of the metal complexes and to calculate the different thermodynamic activation parameters. Experimental The Organic Compounds1) Preparation of 1,1-Oxalylhydrazide: 1,1-oxalyldihydrazine was prepared by adding oxalyl chloride (7 gm, 0.05 mol) to alcoholic solution of hydrazine hydrate (5 gm, 0.1 mole). The reaction mixture was exothermic and left to cool with stirring. A white crystal precipitate was formed and washed with ethanol diethyl ether and left to dry.2) Preparation of 1,1-Oxalylbis (4-phenylthiosemicarbazide): It was prepared by adding phenylisothiocynate (2.8 gm, 0.02 mol) to an alcoholic solution of oxalic acid dihydrazide (1.18 gm, 0.01 mole). The reaction mixture was refluxed f...

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Section: Infrared Spectra Of H 4 Oxtsc (I) and Its Metal Complexesmentioning

confidence: 99%

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Amin¹,

Elreedy²,

Alansi³

et al. 2016

OJIC

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“…Due to their biological activities, such molecules have attracted interest. They have been previously described to present nematocidal, insecticidal, antibacterial, antifungal, antiviral, and anti-inflammatory activities, especially for furan and thiophene side groups [16].…”

Section: Introductionmentioning

confidence: 99%

Platinum(II) and palladium(II) aryl-thiosemicarbazone complexes: synthesis, characterization, molecular modeling, cytotoxicity, and antimicrobial activity

Tavares

Paschoal

Motta

et al. 2014

Journal of Coordination Chemistry

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Platinum(II) and palladium(II) complexes [ML 2 ] have been isolated from reaction of K 2 PtCl 4 or K 2 PdCl 4 and ligands (L) derived from thiosemicarbazones. The complexes were characterized by elemental analysis, Raman, IR, and NMR spectroscopy. In addition, quantum mechanical calculations were used to predict their structures and spectroscopic properties. For the first time, theoretical calculations using 195 Pt NMR data were used to support the suggested structures. The results indicate that the thionic sulfur and the azomethine nitrogen are bonded to the metal ion in a trans configuration. Antibacterial activities and cytotoxicities of the complexes to B16-F10 and CT26.WT cell lines were also investigated. Some of the complexes demonstrated superior cytotoxic activity compared to cisplatin.

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“…Most of these compounds have antifungal [7], antimicrobial [8], antitumor [9], biological activity [10,11] as well as hypoglycemic effects [12][13][14]. In addition, thiosemicarbazide derivatives have ability to form chelate complexes with transition metal ions [15][16][17][18][19][20]. Continuing our studies for the electrochemical synthesis of new metal complexes of ligands containing N, S and O atoms through the reaction of metal ions scarified from the anodic dissolution of metals [16,21,22].…”

Section: Introductionmentioning

confidence: 99%

Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H<sub>4</sub>pClMaTS) synthesized by electrochemical method

Amin¹,

Yamany²,

Abo-Aly³

et al. 2011

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HNMR, mass), thermal, and ESR studies. The Raman and infrared spectral studies suggests the tridentate behavior of the ligand from each tail. Since the ligand has two thiosemicarbazide groups, it may acts in an SNO tridentate fashion from each side with one of the two metal ions forming a polynuclear complex coordinating through both of the lone pair of electrons the enolic oxygen of the carbonyl group (C=O), the azomethine nitrogen (C=N) and the thioenol form of the thiocarbonyl group (C=S). The differential thermogravimetric analysis (DTG) curves were used to study the decomposition steps of the isolated complexes using Horowitz-Metzger (HM) and Coats-Redfern (CR) methods. The kinetic thermodynamic parameters such as: E*, ∆H*, ∆S*and ∆G* are calculated from the DTG curves.

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Transition metal complexes with thiosemicarbazide-based ligands. XLIV. The supramolecular arrangement in the Ni(II) complexes of S-methylisothiosemicarbazide

Cited by 26 publications

References 13 publications

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Platinum(II) and palladium(II) aryl-thiosemicarbazone complexes: synthesis, characterization, molecular modeling, cytotoxicity, and antimicrobial activity

Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H<sub>4</sub>pClMaTS) synthesized by electrochemical method

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Transition metal complexes with thiosemicarbazide-based ligands. XLIV. The supramolecular arrangement in the Ni(II) complexes of S-methylisothiosemicarbazide

Cited by 26 publications

References 13 publications

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

Platinum(II) and palladium(II) aryl-thiosemicarbazone complexes: synthesis, characterization, molecular modeling, cytotoxicity, and antimicrobial activity

Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H&lt;sub&gt;4&lt;/sub&gt;pClMaTS) synthesized by electrochemical method

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Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H<sub>4</sub>pClMaTS) synthesized by electrochemical method