Platinum(II) and palladium(II) aryl-thiosemicarbazone complexes: synthesis, characterization, molecular modeling, cytotoxicity, and antimicrobial activity

Abstract

Platinum(II) and palladium(II) complexes [ML 2 ] have been isolated from reaction of K 2 PtCl 4 or K 2 PdCl 4 and ligands (L) derived from thiosemicarbazones. The complexes were characterized by elemental analysis, Raman, IR, and NMR spectroscopy. In addition, quantum mechanical calculations were used to predict their structures and spectroscopic properties. For the first time, theoretical calculations using 195 Pt NMR data were used to support the suggested structures. The results indicate that the thionic sulfur and the azomethine nitrogen are bonded to the metal ion in a trans configuration. Antibacterial activities and cytotoxicities of the complexes to B16-F10 and CT26.WT cell lines were also investigated. Some of the complexes demonstrated superior cytotoxic activity compared to cisplatin.

New Platinum(II) Triazole Thiosemicarbazone Complexes: Analysis of Their Reactivity and Potential Antitumoral Action

“…For complex 1,h owever, the solubility did allow us to record the 195 Pt NMR spectra,w hich showed only one signal at d = À3614.8ppm. The value we reported herein is in agreement with the only value found in the literature, [10] and even more similar to other coordination compounds containing a{ PtN 2 S 2 } unit. The MS (FAB +)s pectra confirmed the molecular ion signala tm/z 1152 [M] + .…”

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

“…The organisms used in the present investigations included Staphylococcus aureus (S. aureus), Streptococcus features (S. features) and Bacillus subtillis (B. subtilis) (as gram-positive bacteria) and Proteus mirabilis (P. mirabilis), Pseudomonas aereuguinosa (P. aereuguinosa), and Escherichia coli (E. coli) (as gram-negative bacteria). The zone of inhibition of moxifloxacin and its metal complexes against gram-negative and gram-positive bacteria were then evaluated by the well diffusion method (De Almeida et al 2007;Efthimiadou et al 2008;Patel et al 2011;Singh et al 2013;Tavares et al 2004). The results of the bacterial screening of the synthesized compounds were recorded as shown in Table 6.…”

A Palladium Catalyst System for the Efficient Cross-Coupling Reaction of Aryl Bromides and Chlorides with Phenylboronic Acid: Synthesis and Biological Activity Evaluation

“…Three compounds 2b , 3a , and 3b exhibited moderate AChEI activity and the product 2b was the most active, with an acetylcholinesterase inhibitory activity of 38.15% at 100 μg/mL. Though the complexes showed slightly more antibacterial activities than other reported complexes, their strong abilities to bind with DNA and scavenge free radicals compared to other reported palladium complexes was notable [ 27 , 28 , 29 , 30 ].…”