Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H&amp;lt;sub&amp;gt;4&amp;lt;/sub&amp;gt;pClMaTS) synthesized by electrochemical method

The thermogravimetry (TG) and derivative thermogravimetry (DTG) have been used to study the thermal decomposition of some oxalyl (H 4 OxTSC), malonyl (H 4 MaTSC) and succinyl-bis-4-phenylthiosemicarbazide (H 4 SuTSC) ligands and their metal complexes using Horowitz-Metzger (HM) and Coats-Redfern methods. The kinetic thermodynamic parameters such as: E*, ΔH*, ΔS*and ΔG* are calculated from the DTG curves. The isolated complexes have the general composition [M 2 (L) (H 2 O) 6 ], where M=Cu(II), Zn(II), L=MaTSC and M=Co(II), Cu(II) or Sn(II) and L=Su TSC and [M 2 (L) (H 2 O) n ]·nH 2 O where M=Cu(II), Co(II) or Sn(II), L=OxTS or Ma TSC. The tested compounds show a good activity against four strains of bacteria Gram negative Escherichia coli, Pseudomonas aeruginosa species and gram-positive Bacillus cereus and Staphylococcus aureus.Keywords Metal (II) Complexes, Bis-Thiosemicarbazide, Thermogravimetric, Antibacterial Studies 1. Introduction Thiosemicarbazide and its derivatives have received considerable attention because of their pharamacological * Corresponding author.R. R. Amin et al. 90 properties [1]. Thiosemicarbazide complexes show a broad spectrum of anticancer activity [2] [3]. Also, thiosemicarbazide derivatives are of current interest with respect to their uses as analytical reagents for separations of metal(II) ions [4]-[7], analytical determination of metal ions [8] [9], and clinical analysis [10]. Most of these compounds have antifungal [11]-[12], antimicrobial [13] and antitumor activity [14]-[16], as well as radiopharmaceuticals applications [17]. Continuing our studies for the chemical and electrochemical synthesis of new metal complexes of ligands containing N, S and O atoms through the reaction of metal ions scarified from the anodic dissolution of metals [18] [19]. Our aim work in this paper to report novel complexes prepared from the reaction between bisthiosemicarbazi decompounds which have a good ability to form chelate complexes with transition metal [18]- [20]. We report here the thermal, spectral and biological evaluations of Co(II), Cu(II), Zn(II) and Sn(II) complexes for 1,1-oxalyl, malonyl and succinyl-bis-4-phenylthiosemicarbazide ligands. The modern spectroscopic investigations are used to elucidate the structure of the prepared materials. The thermal decomposition is also used to infer the structure of the metal complexes and to calculate the different thermodynamic activation parameters. Experimental The Organic Compounds1) Preparation of 1,1-Oxalylhydrazide: 1,1-oxalyldihydrazine was prepared by adding oxalyl chloride (7 gm, 0.05 mol) to alcoholic solution of hydrazine hydrate (5 gm, 0.1 mole). The reaction mixture was exothermic and left to cool with stirring. A white crystal precipitate was formed and washed with ethanol diethyl ether and left to dry.2) Preparation of 1,1-Oxalylbis (4-phenylthiosemicarbazide): It was prepared by adding phenylisothiocynate (2.8 gm, 0.02 mol) to an alcoholic solution of oxalic acid dihydrazide (1.18 gm, 0.01 mole). The reaction mixture was refluxed f...

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Kinetic parameters and thermal decomposition for Novel 1,1-Malonyl-bis(4-p-Chlorophenylthiosemicarbazide) and Cu(II), Co(II), Zn(II) and Sn(II) complexes(H<sub>4</sub>pClMaTS) synthesized by electrochemical method

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Spectral, Thermal and Antibacterial Studies for Bivalent Metal Complexes of Oxalyl, Malonyl and Succinyl-bis-4-phenylthiosemicarbazide Ligands

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