Transition Metal-Catalyzed Tandem Reactions of Ynamides for Divergent N-Heterocycle Synthesis

Abstract

type of nitrene transfer reagents was disclosed, leading to divergent synthesis of 3-carbonyl-2-aminopyrroles and deacylative 2-aminopyrroles.

Stereoselective Synthesis of Azacycles Induced by Group 8–11 Late Transition Metals

“…[46] The Ye group has been involved in the development of methodologies to transform ynamides to varied nitrogen heterocycles with Cu I catalysis. [47] In one of their recent communications, [47e] the synthesis of chiral pyrrole-fused bridged systems has been described. They reacted alkenyl Npropargyl ynamides and styrene derivatives in the presence of Cu(MeCN) 4 PF 6 In an interesting study, resolutions of N-tosylaziridines were carried out by N-heterocyclic carbene and copper cooperative catalysis.…”

Efficient access to 1,3,4-trisubstituted pyrroles via gold-catalysed cycloisomerization of 1,5-diynes

“…Given the well-established procedures to access diynes, homogeneous catalysis mediated by gold complexes 9 for the construction of N-heterocyclic compounds was widely explored. For example, a variety of functionalized cyclic architectures could be obtained via gold-catalysed reactions of conjugated diynes, 10 1,4-diynes, 11 1,6-diynes, 12 and 1,5-diynes.…”

Step by Step Construction of Multifunctional Hollow Double Shell MNPs@MOF as a Powerful Tandem/Cascade Catalyst

“…Imines (Schiff bases) are widely presented in natural products, bioactive compounds and pharmaceutical structures ( Kobayashi et al, 2011 ; Nielsen et al, 2011 ). It is prevalent in the field of fine chemical, pharmaceutical, and chemical industries and plays an important role in the synthesis of N-containing heterocyclic ( Dhakshinamoorthy and Garcia 2014 ; Bhaskaruni et al, 2020 ; Djakovitch et al, 2011 ) compounds as a nitrogen source ( Shang et al, 2019 ; Chen et al, 2021 ; Long et al, 2017 ; Hong and Ye 2020 ; Chen et al, 2015 ). In particular, the implementation of one-pot tandem/cascade catalytic reactions to realize imines and their derivatives are of the greatest interest to chemical researchers ( Huang et al, 2017 ; Wu et al, 2019 ; Wang et al, 2018 ).…”