Transition-metal-catalyzed C–H bond alkylation using olefins: recent advances and mechanistic aspects

Abstract

Transition metal catalysis has contributed immensely to C–C bond formation reactions over the last few decades, and alkylation is no exception.

Recent Advances in Rhodium‐Catalyzed Electrochemical C−H Activation

“…Derivatization of aryl-and heteroaryl bio-relevant molecules with alkyl groups are of great interest due to specific roles of alkyl groups in modulation of molecular properties. [118][119][120][121] In this context, recently, the Ackermann group was successfully applied rhodaelectro catalysis for the challenging methylation, ethylation and propylation of (hetero)arenes using trifluoroborates as alkylating agents. [122] The reaction conveniently performed in an undivided cell setup using nBuOH/H 2 O as the reaction media.…”

Oxidative C(sp3)−N Cleavage Cascade Cyclization of N‐Uracil Amidines and Tertiaryamines: Switchable Divergent Synthesis of Functionalized Pyrimidouracils and Dihydropyrimidouracils

“…Switchable divergent reactions are recognized as promising synthetic protocols for constructing N-heterocycle skeletons with heightened structural diversity and complexity, in which the products can be switched as required by changing the substrates or reaction conditions. [15] On the other hand, the C(sp 3 )À N bond cleavage cascade reaction has provided a practical and pliable strategy to develop new synthetic methods for achieving the polycyclic N-heterocycles. [16] Compared with the extensive explorations in the fields of C(sp 2 )À N bond cleavage, [17] the advances in cleavage of C(sp 3 )À N have fallen significantly behind due to the high C(sp 3 )À N bonds dissociation-energy and the inert nature.…”

Annulation of enaminones with quinonediimides/quinoneimides for selective synthesis of indoles and 2-aminobenzofurans

“…The direct activation or functionalization of C–H bonds offers powerful tools for the synthesis of numerous functional molecules. 1 One representative application of such bond transformation is the construction of heterocycles by means of either direct intramolecular or cascade ring formation. 2 Accordingly, as fundamental and highly useful heterocyclic motifs, the indoles and benzofurans have been reported to be accessible by different methods based on the conversion of C–H bonds.…”