Transient sixth cranial nerve palsy following orgasm abrogated by treatment with sympathomimetic amines

Jh, Check; Katsoff, B

doi:10.12891/ceog17772014

Cited by 7 publications

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“…Dextroamphetamine sulfate was found to be highly eff ective for various types of pelvic pain including chronic pelvic pain, mittelschmerz, dyspareunia, vulvovaginitis, dysmenorrhea, and vaginismus [38][39][40][41][42].…”

Section: Dopaminergic Drugs To Treat Medical Conditions Only Found In...mentioning

confidence: 99%

“…However, if there is borderline increased cellular permeability in other tissues the increase in serum progesterone may now increase the permeability of that given tissue above a critical level leading to infi ltration of irritants with subsequent increased infl ammation and subsequently symptoms related to the infl ammation of that tissue. Thus, in some instances interstitial cystitis and migraine headaches may only occur in the luteal phase [39]. Dextroamphetamine has been shown to be benefi cial for interstitial cystitis, migraine headaches and dyspareunia that only occurs in the luteal phase [39].…”

Section: Dopaminergic Drugs To Treat Medical Conditions That Only Occ...mentioning

confidence: 99%

“…Thus, in some instances interstitial cystitis and migraine headaches may only occur in the luteal phase [39]. Dextroamphetamine has been shown to be benefi cial for interstitial cystitis, migraine headaches and dyspareunia that only occurs in the luteal phase [39].…”

Section: Dopaminergic Drugs To Treat Medical Conditions That Only Occ...mentioning

confidence: 99%

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Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

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2024

J Biomed Res Environ Sci

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Based on a conglomeration of basic science research studies a model of hypothetical mechanisms of how the fetal semi-allograft can develop into a live baby was created. One of the tenets of the model is that it is necessary to remodel some of the typically thick-walled uterine arteries found during the proliferative phase into thin-walled spiral arteries to allow nutrient exchange between mother and fetus through an autoimmune mechanism during the luteal phase. The model suggests that the rise in progesterone inhibits dopamine. One function of dopamine is to diminish cellular permeability allowing irritants to infuse into the endometrium thus evoking an inflammatory reaction. The body must suppress these cellular immune cells from attacking the fetus. Progesterone activates membrane progesterone receptors which produces immunomodulatory proteins e.g., the Progesterone Induced Blocking Factor (PIBF), which negates the killing effect of cellular immunity. One hypothesis suggested that PIBF may be secreted by malignant tumors facilitating these tumors with foreign antigens to escape immunosurveillance and thus metastasize. Progesterone receptor antagonists e.g., mifepristone, which suppresses PIBF, have successfully increased length and quality of life in patients with a large variety of end stage treatment resistant cancers. Excessive permeability of various tissues was hypothesized to be related to possible relative deficiency of dopamine. A large variety of medical conditions have been ameliorated significantly by the use of dopaminergic drugs e.g. dextroamphetamine or cabergoline. The model explains why certain conditions may get worse premenstrually e.g., pelvic pain or headaches by the added suppressive effect of progesterone on dopamine. Though possibly further research may modify this model, based on the present hypothesis, a large number of treatment refractory conditions had very successful improvement based on treating with drug releasing dopamine thus correcting tissue permeability disorders.

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Section: Dopaminergic Drugs To Treat Medical Conditions Only Found In...mentioning

confidence: 99%

Section: Dopaminergic Drugs To Treat Medical Conditions That Only Occ...mentioning

confidence: 99%

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Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

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2024

J Biomed Res Environ Sci

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“…Sympathetic tone is then restored by treatment with the sympathomimetic amine dextroamphetamine sulfate. A vivid example of the manifestation occurring only with a further impairment of the sympathetic nervous system was a woman who had diploplia with paresis of the extraocular muscles for 30 minutes only when she had an orgasm [12]. Her sixth cranial nerve palsy was abrogated by treatment with dextroamphetamine sulfate.…”

Section: Introductionmentioning

confidence: 99%

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

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2019

Clin. Exp. Obstet. Gynecol.

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Purpose: To see if the use of sympathomimetic amines, which have been shown to treat cases of hives, can help prevent cyclical urticaria and anaphylaxis associated with the late luteal phase that was resistant to standard treatment. Materials and Methods: Treatment with low dose dextroamphetamine sulfate to gain relief of symptoms was given to one young woman whose urticaria only occurred premenstrually, but was also associated with life threatening anaphylaxis. Patient 2 had chronic daily urticaria which was exacerbated premenstrually. Results: Both patients showed prompt 100% improvement in the urticaria. Patient 2 after 20 years of therapy ran out of medication for one month. Her severe urticaria quickly returned only to dissipate when dextroamphetamine sulfate was restarted. Conclusion: Use of dextroamphetamine sulfate was successful in treating the anaphylaxis and extensive luteal phase hives in patient 1 as well as treating chronic hives with a premenstrual exacerbation in patient 2. These cases are both consistent with the proposed mechanism of the sympathetic neural hyperalgesia edema syndrome, i.e., increased cellular permeability related to sympathetic nervous system hypofunction of specific permeability defects of certain tissues. In these cases, the hypothesis is that the increased permeability manifests as leakage from the vesicles that contain the histamines.

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“…Other conditions improved by dextroamphetamine sulfate did not involve pain either [16][17][18][19][20][21][22]. Thus we considered other names.…”

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confidence: 99%

Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome

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2017

Clin. Exp. Obstet. Gynecol.

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I wrote an editorial entitled "Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy" [1]. Since we have written a large number of case reports and a previous editorial on treating pelvic pain, hopefully some of our readers have tried this therapy even before the last editorial. If not, from these past case report studies, hopefully the last editorial has convinced you to try this therapy for a variety of female disorders [1]. If you have tried it, I know you and your patients are very satisfied.This condition is not limited to women but seems to be more common (similar to autoimmune disorders). In fact, I think this condition, that we have referred to as the sympathetic neural hyperalgesia edema syndrome, plays a critical role in most autoimmune disorders. A large majority of so-called autoimmune diseases are much more effectively treated by dextroamphetamine sulfate rather than glucocorticoids and/or biological immunosuppressives with far less risk and much less expense when compared to the biologicals.This condition is extremely common, yet it is unknown to most clinicians with the exception of the readership for Clinical and Experimental Obstetrics & Gynecology. The reason for this is that it is not being promulgated by large pharmaceutical companies because dextroamphetamine sulfate is available as a generic drug. Furthermore, the plethora of published articles would prevent a large pharmaceutical company from obtaining a patent even if they made some slight modifications to the formulation.Probably the first name given to a form of this condition was provided by George Thorn (who was the head of endocrinology at Harvard Medical School) over 45 years ago and he used the name "idiopathic edema" [2]. He also called it "periodic swelling" [2]. Since the condition became worse from morning until evening, and it was clear that standing erect made the condition worse, I sometimes referred to the condition as idiopathic orthostatic edema [3].

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Transient sixth cranial nerve palsy following orgasm abrogated by treatment with sympathomimetic amines

Cited by 7 publications

References 0 publications

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Most Chronic Medical Conditions in Women are related to Increased Cellular Permeability and most can be Effectively Treated with Dopaminergic Drugs

Use of sympathomimetic amines to correct premenstrual urticaria and anaphylaxis

Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome

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