Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome

Abstract

I wrote an editorial entitled "Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy" [1]. Since we have written a large number of case reports and a previous editorial on treating pelvic pain, hopefully some of our readers have tried this therapy even before the last editorial. If not, from these past case report studies, hopefully the last editorial has convinced you to try this therapy for a variety of female disorders [1]. If you have tried it, I know you and your patients are very satisfied.This condition is not limited to women but seems to be more common (similar to autoimmune disorders). In fact, I think this condition, that we have referred to as the sympathetic neural hyperalgesia edema syndrome, plays a critical role in most autoimmune disorders. A large majority of so-called autoimmune diseases are much more effectively treated by dextroamphetamine sulfate rather than glucocorticoids and/or biological immunosuppressives with far less risk and much less expense when compared to the biologicals.This condition is extremely common, yet it is unknown to most clinicians with the exception of the readership for Clinical and Experimental Obstetrics & Gynecology. The reason for this is that it is not being promulgated by large pharmaceutical companies because dextroamphetamine sulfate is available as a generic drug. Furthermore, the plethora of published articles would prevent a large pharmaceutical company from obtaining a patent even if they made some slight modifications to the formulation.Probably the first name given to a form of this condition was provided by George Thorn (who was the head of endocrinology at Harvard Medical School) over 45 years ago and he used the name "idiopathic edema" [2]. He also called it "periodic swelling" [2]. Since the condition became worse from morning until evening, and it was clear that standing erect made the condition worse, I sometimes referred to the condition as idiopathic orthostatic edema [3].

The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence

“…The increased cellular permeability syndrome is the etiologic factor for a wide variety of chronic conditions that are refractory to standard therapies that have in common very good improvement following treatment with dextroamphetamine sulfate [15,16]. The conditions that improve include pelvic pain of various types, with or without the presence of endometriosis, and migraine headaches, chronic fatigue and fibromyalgia (as seen in the patient described), neuromuscular disorders, bowel motility disorders (e.g., achalasia, gastroparesis, or pseudointestinal obstruction), chronic urticaria, arthritis, and chronic regional pain syndrome.…”

“…Dextroamphetamine sulfate is believed to improve the various manifestations of this syndrome by releasing dopamine from sympathetic nerve fibers. One of the functions of dopamine is to decrease cellular permeability [15,16].…”

“…The urethral closure mechanism requires both functioning musculature and nerve innervations to accomplish the normal urethral closure mechanism. The tenets of the hypothetical way that the increased cellular permeability causes disruption of normal organ function, and in this case the urethral closure mechanism, is that toxic elements permeate these tissues, which is improved when more dopamine is released by sympathomimetic amine therapy [16]. Sometimes pain or organ dysfunction occurs, after an injury, theoretically leaving the affected individual with a permeability disorder, which may also respond to dextroamphetamine sulfate, even when other treatments are ineffective [16].…”

“…A case is presented of a woman with severe idiopathic urgency incontinence who failed to improve despite mirabegron treatment, but demonstrated marked improvement with the sympathomimetic amine dextroamphetamine sulfate, a very effective drug for a variety of conditions that are part of the increased cellular permeability syndrome [15,16].…”

Sympathomimetic amine therapy abrogates severe long-term unexpalined abdominal pain and diarrhea (microscopic colitis) - possible infertility implications

“…A condition has been described related to increased cellular permeability leading to a variety of medical conditions related to an inflammatory response to unwanted absorption of toxic elements, or muscle dysfunction related to toxic chemicals disrupting skeletal and/or small muscle function [1][2][3]. This condition was previously referred to as the sympathetic neural hyperalgesia edema syndrome, but is now called the increased cellular permeability syndrome, and it is more common in women [4]. This condition may have an adverse effect on fecundity by causing a constant inflammatory state, and thus the presence of an increased cellular immune response past the normal six-days postovulation, making it more difficult for progesterone to stimulate a sufficient amount of immunomodulatory proteins to negate these white blood cells (especially natural killer cells) from causing immune rejection of the fetal semi-allograft [5][6][7][8][9].…”