This study examines two descriptive parameters of embryo morphology to determine if either parameter correlates with subsequent pregnancy rates (PRs). The two parameters were the evenness (similarity in size) of the blas-tomeres and the degree of cellular fragmentation. A total of 242 embryo transfers in which 4 embryos were transferred were included. Sixty-nine (28.5%) clinical and 62 (25.6%) viable pregnancies resulted. In all cases 4 embryos were transferred, but the number of embryos with even round blastomeres (grade 1) varied from 0 to 4. Statistically, there was no correlation between PR and number of grade 1 embryos transferred. When 4 grade 1 embryos were transferred, the PR was 33.3 versus 28.1% when no grade 1 embryos were transferred. There was, however, a statistical difference in the implantation rate; a higher frequency of multiple gestations occurred when 3 or 4 of the embryos transferred were graded 1:12.7 as compared with 6.7% when < 2 embryos were grade 1. The significance of the degree of cellular fragmentation in the embryos was also assessed. There was no statistical difference in the PR according to the number (0–4) of embryos transferred that did not have fragments (grade A). When 4 grade A embryos were transferred, the PR was 18.2 versus 26.1 % when there were no grade A embryos. Neither implantation nor multiple-birth rates correlated with fragmentation.
To determine if treatment with dextroamphetamine sulfate can reduce pelvic pain that was attributed to adenomyosis. Materials and Methods: Dextroamphetamine sulfate was given to a 32-year-old woman who suffered on a daily basis from severe chronic pelvic pain that was not relieved by laparoscopic removal of endometriosis by oral contraceptive and ibuprofen. The adenomyosis was diagnosed by magnetic resonance imaging. Results: Within three months the pain was completely gone and has remained absent for six months. Conclusions: Dextroamphetamine sulfate relieved pain from adenomyosis similar to its effect on endometriosis.
To show that a common but not well-known disorder of the sympathetic nervous system can present with symptoms suggesting a pheochromocytoma. Materials and Methods: The standard treatment of this disorder (which is characterized by an abnormal water load test), i.e., sympathomimetic amine therapy, was given to a woman with paroxysmal tachycardia and hypertension. Results: Over a period of six months, the treatment eradicated the paroxysmal symptoms to which all other therapies had failed. Conclusions: This condition recently named as sympathetic neural hyperalgesia edema syndrome can present with symptoms of a pheochromocytoma and will respond to therapy with low dosages of dextroamphetamine sulfate.
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