Transient, secondary hypoadrenocorticism after treatment with delmadinone acetate (Tardastrex®) in a two year old male dog

Abstract

A two year old male Labrador Retriever was treated with delmadinone acetate because of benign prostatic hyperplasia. Four days after the injection the dog showed gastrointestinal signs and a progressive lethargy. In the hospital for small animals of the Justus-Liebig-University of Gießen an ACTH stimulation test was done and a secondary hypoadrenocorticism was diagnosed. The dog was treated with prednisolone in physiological dose for 14 weeks after the injection. The clinical symptoms stopped immediately. A new ACTH stimulation test some weeks later showed a completely normal adrenal function.

Morbus Addison beim Hund – Eine aktuelle Übersicht

“…In der Literatur finden sich Hinweise, dass Ketokonazol und Delmadinoacetat (Tardastrex ® ) zu einem transienten Hypoadrenokortizismus führen können [10,11].…”