Transient Neonatal Myasthenia Gravis in a Baby Born to a Mother With New-Onset Anti-MuSK-Mediated Myasthenia Gravis

Abstract

We describe a 30-year-old pregnant woman with undiagnosed weakness who delivered a severely weak neonate. Subsequent workup of the mother revealed myasthenia gravis with muscle-specific kinase antibodies. The infant responded to intravenous immunoglobulin and symptoms normalized. He was presumed to have an anti-muscle-specific kinase-mediated transient neonatal myasthenia gravis.

Selective response to rituximab in a young child with MuSK-associated myasthenia gravis

“…Our patient also had predominant ocular and bulbar symptoms but showed a younger age of onset, with initial symptoms at age 3 months with more overt features by age 5 years. A case of transient neonatal MuSK myasthenia has also been described [5].…”

Neonatal autoimmune diseases: A critical review

“…Severe neonatal myasthenia gravis has been reported to be associated with maternal anti-MuSK antibodies [107]. Another report described the successful treatment of neonatal myasthenia gravis with intravenous immunoglobulin [108].…”

Juvenile Myasthenia Gravis: A Report of Three Cases and Literature Review

“…Annenin tedavi edilmediği durumlarda, sonraki bebeklerin tamamında hastalık görülmektedir. Maternal MuSK antikorlarına bağlı neonatal MG nadir de olsa bildirilmiş-tir [15]. Hatta bir olguda, annede tanı neonatal MG tanısı konulduktan sonra konulmuştur [15].…”

“…Maternal MuSK antikorlarına bağlı neonatal MG nadir de olsa bildirilmiş-tir [15]. Hatta bir olguda, annede tanı neonatal MG tanısı konulduktan sonra konulmuştur [15]. Olgularımızda dismorfik görü-nüm, eklem kısıtlılığı, annede MG öyküsü ve nörolojik muayenede MG şüphesi olmadığı için neonatal MG dışlandı.…”