Transfusion Therapy in Cooley's Anemia: Growth and Health as Related to Long‐Range Hemoglobin Levels. A Progress Report

Wolman, Irving J.

doi:10.1111/j.1749-6632.1965.tb54075.x

Cited by 128 publications

(31 citation statements)

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“…Although iron chelating agents such as Desferal (Ciba) may reduce such condition, not every child can afford the medicine. High regimen of blood transfusion as recommended by Wolman ( 1964) seems to be of no benefit in our material, due to some situational difficulties such as communication and socio-economic condition of the patients· In our clinic in Jakarta we prefer to maintain the hemoglobin at a "safe" level where the child is still active without any complaint caused by anemia.…”

Section: Problems Concerning the P(ltierdsmentioning

confidence: 93%

“…The main controversy is whether an attempt should be made to keep the hemoglobin content at a "normal" level or whether the child should be transfused at intervals, sufficient to keep a "safe" level of hemoglobin without showing any symptoms attributable to anemia. Wolman (1964), Wolman and Ortolani (1969), showed a better development of ~their patients after being maintained at a high hemoglobin level. On the other hand this high transfusion regime may lead to several complications such as iron overload, increase the possibility of serum hepatitis, formation of antibodies and other transfusion reactions.…”

Section: Introductionmentioning

confidence: 95%

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Some Problems of Thalassemia in Jakarta

Wahidiyat

Markum

Abdulsalam

et al. 2017

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Section: Problems Concerning the P(ltierdsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 95%

Some Problems of Thalassemia in Jakarta

Wahidiyat

Markum

Abdulsalam

et al. 2017

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“…Ayrıca bulaş yolları arasında kan transfüzyonunun da önemli bir yer tuttuğu bilinmektedir (5). Talasemi majorlü hastalarda tedavi amacıyla çok sık kan transfüz-yonu yapıldığı bilinmektedir (6).…”

Section: Introductionunclassified

Investigation of Anti-Toxoplasma gondii IgG and IgM Antibodies in Beta Thalaseamia Major Patients in Aydın Province

Karakaş¹,

Özlem²,

Tellioğlu³

et al. 2012

Turkiye Parazitol Derg

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ÖZETAmaç: Talasemili hastalarda tedavi amacıyla uygulanan kan transfüzyonu ile alıcılara bazı enfeksiyon etkenleri bulaşabilmektedir. Toxoplasma gondii, transfüzyonla geçebilen bir parazit etkeni olması nedeniyle bu çalışmada anti-Toxoplasma antikorlarının araştırılması amaçlanmıştır. Yöntemler: Yaşları 4 ile 35 (ort. 18.11±8.31) arasında değişen 36 talasemi olgusu ile sağlıklı aynı yaş ve cinsiyete göre birebir eşleşme yöntemi ile seçilen 36 olgu arasında Enzyme-Linked Immunosorbant Assay (ELISA) tekniği kullanılarak Toxoplasma'ya karşı oluşan antikor (IgG, IgM) seviyeleri araştırılmıştır. Bulgular: Talasemi major tanısı konmuş ve takipleri yapılan 7 olguda (%19.4) parazite özgü IgG antikoru, 2 olguda (%5.5) sınır değerlerde (borderline) IgM antikoru saptanmıştır. Kontrol grubundaki 5 olguda (%14) parazite özgü IgG antikoru saptanmıştır. Borderline çıkan olguların serum örnekleri ile avidite tesiti çalışılmış ve yüksek avidite olarak bulunmuştur. Talasemi majorlü olgular ile kontrol grubu anti-Toxoplasma IgG antikorlarının varlığı açısından karşılaştırıldığında Talasemi majorlü grupta kontrol grubuna göre anlamlı fark bulunamamıştır (p=0.752). Sonuç: İstatistiksel olarak anlamlı fark saptanmamış olmakla birlikte tedavi amacıyla çok sayıda kan transfüzyonuna gereksinim duyulan Talasemi gibi özel olgu gruplarında vericilerin Toxoplasma gondii gibi kan transfüzyonu ile bulaşan enfeksiyonlar açısından değerlendirilmesi ve bu enfeksiyon etkeninin göz ardı edilmemesi gerektiği kanısına varılmıştır. (Turkiye Parazitol Derg 2012; 36: 133-6) Anahtar Sözcükler: Toxoplasma gondii, Talasemi major, transfüzyon, Aydın Geliş Tarihi: 09.03.2012Kabul Tarihi: 09.07.2012 ABSTRACTObjective: Blood transfusion therapy for Thalassaemia patients may cause transmission of some infectious agents to the recipients. As Toxoplasma gondii is a transfusion-transmitted parasite, we aimed to investigate anti-Toxoplasma antibodies. Methods: We arranged two groups: patients and controls. There were 36 Thalassaemia cases in the patient group. The control group also included 36 healthy people (of the same ages and gender) who were selected by the one-to-one mapping method. Mean age was 18.1±8.3 (4-35). Toxoplasma gondii IgG and IgM antibodies were analyzed by the Enzyme-Linked Immunosorbant Assay (ELISA).Results: We determined parasite-specific Toxoplasma gondii IgG antibodies in 7 (19.4%) and borderline levels of IgM antibody in 2 Thalassaemia major cases (5.5%). In the control group, parasite-specific IgG antibody was found in 5 cases (14%). Serum samples of patients with borderline levels were analyzed with an avidity test and were found to have high avidity. There were no significant differences between patient and control groups when considering the presence of anti-Toxoplasma IgG antibodies (p=0.752). Conclusion: Although there is no significant statistical difference, we suggest that blood transfusion donors should be investigated for infectious agents such as Toxoplasma gondii. (Turkiye Parazitol Derg 2012; 36: 133-6)

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“…When David and I began our efforts in the early 1960s, the only effective treatment of thalassemia was blood transfusion, and that one weak reed was handled poorly. Only the efforts of Wolman in Philadelphia3 and later Piomelli in New York4 convinced us to maintain the patient's hemoglobin higher than the usual 6 to 8 grams per 100 mL. The simple act of suppression of erythropoiesis with sufficient red cell transfusion would at least blunt the massive ineffective erythropoiesis and attendant bony destruction, heart failure, and organ infiltration that characterize beta thalassemia.…”

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confidence: 99%

Thalassemia: The Continued Challenge

Nathan¹

2005

Annals of the New York Academy of Sciences

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This overview describes the history of transfusion therapy and consequent iron overload in thalassemia. It emphasizes the importance of measurement of hepatic iron and reviews the history of chelation therapy. It briefly describes the discoveries of the genetic basis of thalassemia and the application of that knowledge in prenatal diagnosis. The review goes on to emphasize pharmaceutical efforts to induce fetal hemoglobin synthesis in thalassemic red cells and ends with a discussion of oral iron chelators, stem cell transplant, and the status of gene therapy.

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Transfusion Therapy in Cooley's Anemia: Growth and Health as Related to Long‐Range Hemoglobin Levels. A Progress Report

Cited by 128 publications

References 0 publications

Some Problems of Thalassemia in Jakarta

Some Problems of Thalassemia in Jakarta

Investigation of Anti-Toxoplasma gondii IgG and IgM Antibodies in Beta Thalaseamia Major Patients in Aydın Province

Thalassemia: The Continued Challenge

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