Transforaminal thoracic interbody fusion

Yu, Lingjia; Li, Wenjing; Guo, Shigong; Zhao, Yu

doi:10.1007/s00132-018-3588-6

Cited by 10 publications

(10 citation statements)

References 18 publications

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“…[1][2][3] Of note, a good neurological recovery has an intimate relationship not only with adequate decompression but also with the stability of the spinal column. [7] Reviewing the previous literature, the main treatment for thoracic degenerative spondylolisthesis has been surgical decompression using shortsegment laminectomy in addition to pedicle screw fixation and posterolateral fusion. [1][2][3] However, there are many shortcomings in this procedure, such as insufficient decompression, difficulties in restoring segmental stability, the height of intervertebral disc space and reduction.…”

Section: Discussionmentioning

confidence: 99%

“…However, this surgical approach is not without shortcomings. [7] Patients undergoing TTIF should be informed of the risk of pneumothorax. Additionally, the height and depth of the disc space is considerably smaller in the thoracic spine compared to the lumbar spine.…”

Section: Discussionmentioning

confidence: 99%

“…TTIF can be a useful option for decompressive and reconstructive surgery of the mid and lower thoracic spine. [7,8] In short, the TTIF approach can be a safe and useful method for providing interbody fusion and reconstructing the thoracic spine. As for thoracic degenerative spondylolisthesis, posterior decompression with posterolateral fusion or TTIF were the main treatment modalities, however, TTIF has its unique advantages because of sufficient decompression, immediate stability and high fusion rate.…”

Section: Discussionmentioning

confidence: 99%

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Thoracic degenerative spondylolisthesis-associated myelopathy

Wang¹,

Lin²,

Liang³

et al. 2021

Medicine

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Rationale:The thoracic spine is stabilized in the anteroposterior direction by the rib cage and the facet joints, thus thoracic degenerative spondylolisthesis is very uncommon. Here, we report a rare case of thoracic degenerative spondylolisthesis in which the lower thoracic region was the only region involved.Patient concerns:We present the case of a 56-year-old Chinese female who suffered from thoracic degenerative spondylolisthesis. She had a 2-year history of gait disturbance and bilateral lower-extremity numbness. The initial imaging examinations revealed Grade I anterior spondylolisthesis and severe cord compression, as well as bilateral facet joint osteoarthritis at T11/12.Diagnosis:The patient was diagnosed with thoracic degenerative spondylolisthesis-associated myelopathy.Interventions:She underwent a posterior decompression with transforaminal thoracic interbody fusion (TTIF) at T11/12.Outcomes:The patient recovered well after the operation, and MRI at 12-month follow-up revealed that spinal cord compression was relieved and high signal intensity in T2-weighted image was improved.Lessons:To the best of our knowledge, this is the first reported case of thoracic degenerative spondylolisthesis in which the lower thoracic region was the only region involved. Disruption of joint capsule, instability with micromotion, and degenerative disc may contribute to this rare disease. Posterior decompression with posterolateral fusion or TTIF were the main treatment modalities, however, TTIF has its unique advantages because of sufficient decompression, immediate stability and high fusion rate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Thoracic degenerative spondylolisthesis-associated myelopathy

Wang¹,

Lin²,

Liang³

et al. 2021

Medicine

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“…Although a variety of surgical treatment methods have been reported, there is currently no standard method available for the effective treatment of T-OPLL. Furthermore, the post-operative complication rate is 9.6-40.8% (3–5), and the cause of neurological deterioration in the early post-operative period is unclear. Therefore, numerous studies have focused on elucidating the pathogenesis of T-OPLL.…”

Section: Introductionmentioning

confidence: 99%

Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament

et al. 2019

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The thoracic ossification of the posterior longitudinal ligament (T-OPLL) can cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. Our previous whole-genome sequencing study first reported rs199772854 in the interleukin 17 receptor C ( IL17RC ) gene as a potentially pathogenic loci for T-OPLL. The aim of the present study was to examine the effects of the IL17RC gene rs199772854A site mutation on osteogenesis by establishing a model of osteogenic differentiation. IL17RC gene mutation site and wild-type site mouse embryonic osteoblast (3T3-E1) models were constructed in order to induce the differentiation of the cells into osteoblasts. Whether the mutation site causes the abnormal expression of the IL17RC gene and osteogenic markers was analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis. The IL17RC gene rs199772854A site mutation was demonstrated to play a biological role through the overexpression of its own gene, and also to significantly increase the expression levels of osteogenic markers. Furthermore, the mutation upregulated the expression of the key proteins, tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) and nuclear factor (NF)-κB, in the interleukin (IL)-17 signaling axis. On the whole, the findings of this study suggest that the IL17RC gene rs199772854A loci mutation propels mouse embryonic osteoblasts towards osteogenic differentiation and may play an important role in the pathogenesis of T-OPLL. The IL17RC gene may promote osteogenesis through the IL-17 signaling pathway and may thus be involved in the process of ectopic osteogenesis in T-OPLL.

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“…Conservative treatments are typically ineffective for T-OPLL, with surgery as the only effective treatment. However, due to the unique anatomy and pathophysiological factors associated with for T-OPLL, postoperative cerebrospinal fluid leakage, paraplegia, infection, and other complications are common, occurring in 9.6–40.8% of patients that receive surgical treatment [3–5], and the pathogenesis of T-OPLL remains unclear. Most studies suggest that C-OPLL is a ‘genetic’ disease [6–16], the thoracic spine experiences less local biological stress than the cervical spine; thus, we speculate that genetic factors may contribute to the development of T-OPLL.…”

Section: Introductionmentioning

confidence: 99%

IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament

Wang¹,

Liu²,

Liu³

et al. 2019

J Orthop Surg Res

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Background Thoracic ossification of the posterior longitudinal ligament (T-OPLL) can cause thoracic spinal stenosis, which results in intractable myelopathy and radiculopathy. The etiology of T-OPLL is unknown and the condition is difficult to treat surgically. Whole-genome sequencing identified a genetic variant at rs199772854 of the interleukin 17 receptor C (IL17RC) gene as a potentially pathogenic locus associated with T-OPLL. We aimed to determine whether the rs199772854A site mutation causes abnormal expression of the IL17RC in Han Chinese patients with T-OPLL and predict the possible pathogenic mechanisms of T-OPLL. Analyses were performed to determine whether IL17RC is involved in the pathogenicity of T-OPLL. Methods Peripheral blood and OPLL tissue were collected from a total of 72 patients with T-OPLL disease (36 patients carrying the rs199772854A site mutation in IL17RC and 36 wild-type patients). The expression of IL17RC was analyzed by enzyme-linked immunosorbent assay, reverse transcription-quantitative polymerase chain reaction, immunohistochemistry, and Western blotting. Results rs199772854A mutation resulted in markedly increased IL17RC gene expression levels in peripheral blood samples and the OPLL tissue obtained following clinical surgery ( P < 0.05). Conclusions The results suggest that the rs199772854A site mutation of IL17RC can significantly increase the expression of IL17RC. The IL17RC gene rs199772854A site polymorphism is a potential pathogenic mutation in T-OPLL disease, which may be associated with the occurrence of T-OPLL.

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Transforaminal thoracic interbody fusion

Abstract: The use of TTIF with cage application can be an effective treatment method of thoracic myelopathy caused by anterior compression, with favorable efficacy and safety.

Cited by 10 publications

References 18 publications

Thoracic degenerative spondylolisthesis-associated myelopathy

Thoracic degenerative spondylolisthesis-associated myelopathy

Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament

IL17RC affects the predisposition to thoracic ossification of the posterior longitudinal ligament

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