Transferrin variants in Korea and Japan

Kirk, R. L.; Matsumoto, Hideo; Katayama, Ken‐ichi

doi:10.1007/bf01871376

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In Japanese populations, Parker and Bearn (1961), Matsumoto (1964), Omoto and Harada (1972), and Kirk et al (1978) have reported rare electrophoretic variants. Ferrell et al (1977), examining 4,029 Japanese residing in Hiroshima and Nagasaki, reported three types of B-variant and five types of D-variant.…”

Section: Introductionmentioning

confidence: 98%

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

et al. 1985

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SummaryA multiplicity of transferrin variants have been detected in the course of the biochemical aspect of the study of the genetic effects of atomic bombs. Variants obtained from the studies of 19,770 individuals in Hiroshima and Nagasaki were compared by polyacrylamide slab gel electrophoresis using three kinds of buffer systems with different pH values and thin layer polyacrylamide gel isoelectric focusing. The variants were compared on the basis of their relative mobilities and isoelectric points; seven types of fast-moving variant (B-variant) and nine types of slow-moving variant (D-variant) were detected, involving a total of 154 and 273 individuals, respectively. All the variants were identified as genetic variants by family studies. No variant differed in allele frequency between the two cities. The variants detected in this study were compared with variants detected in residents of Mie district (another Japanese population), Caucasoids, American blacks, and Amerindians. Six additional types of Bvariant and four additional types of D-variant, which had not been detected in Hiroshima and Nagasaki, were identified.

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Section: Introductionmentioning

confidence: 98%

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

et al. 1985

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“…Separation of the genetic variants of the human serum transferrin using electrophoresis in starch gel (Smithies, 1957), agarose gel (Teisberg, 1970) and polyacrylamide gel (Kirk et al, 1978) have shown a common transferrin type, termed transferrin C. It has a frequency of about 98~ or more in all populations so far investigated. Several transferrin variants have also been reported: B variants which have faster and D variants which have slower electrophoretic mobility than transferrin C (Giblett, 1969).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism of transferrin in Egyptians: Analysis by two electrofocusing methods with description of unusual B variant

1985

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SummaryTwo different electrofocusing procedures were employed for investigating the genetic variants of the human transferrin (Tf) in a population sample of 161 unrelated Egyptians. Five common transferrin C subtypes, CI, C1C2, C1C3, C2 and C2C3, and four rare variants, two slow and two fast variants which included unusual double-banded B variant have been demonstrated. The estimated allele frequencies were Tfcl= 0.764, TFC2=0.193, TfC3=0.031, and TfD=0.006. The combined frequencies for the Tf B were 0.006. The observed and expected phenotypes provide a good fit to the Hardy-Weinberg equilibrium.

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A new procedure for the determination of transferrinC (TfC) subtypes by isoelectric focusing

et al. 1980

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Isoelectric focusing (IEF) is widely used for the determination of serum protein polymorphisms in forensic investigations. Because of non-genetic heterogeneity of some proteins and of protein-ligand dissociation observed after IEF standardization of procedures is necessary. In this article the authors point out the main difficulties encountered in studying the transferrin subtype polymorphism and describe a new and sensitive method. Two new Tf C subtypes were observed: Tf C4 in North American, Bolivian and Brazilian Indians, Tf C5 in Black Americans, both with polymorphic allele frequencies. In a Pyrenean population the allele frequencies for Tf C1, Tf C2 and Tf C3 were quite similar to those observed in a German population sample.

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Transferrin variants in Korea and Japan

Cited by 4 publications

References 5 publications

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

Electrophoretic variants of blood proteins in Japanese VI. Transferrin

Genetic polymorphism of transferrin in Egyptians: Analysis by two electrofocusing methods with description of unusual B variant

A new procedure for the determination of transferrinC (TfC) subtypes by isoelectric focusing

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