Genetic polymorphism of transferrin in Egyptians: Analysis by two electrofocusing methods with description of unusual B variant

Abstract

SummaryTwo different electrofocusing procedures were employed for investigating the genetic variants of the human transferrin (Tf) in a population sample of 161 unrelated Egyptians. Five common transferrin C subtypes, CI, C1C2, C1C3, C2 and C2C3, and four rare variants, two slow and two fast variants which included unusual double-banded B variant have been demonstrated. The estimated allele frequencies were Tfcl= 0.764, TFC2=0.193, TfC3=0.031, and TfD=0.006. The combined frequencies for the Tf B were 0.006. The observed and expected phenotypes provide a good fit to the Hardy-Weinberg equilibrium.

Distribution of α₂HS-Glycoprotein Types in Egyptian

“…Blood samples were collected, separated, transported and stored as previously described (SEBETAN et al, 1985). 95 serum samples were subjected to this investigation.…”