2015
DOI: 10.3109/15513815.2015.1095260
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Transferrin Sialylation in Smoking and Non-Smoking Pregnant Women with Intrauterine Growth Restriction

Abstract: Transferrin (Tf) is a glycosylated protein responsible for transporting iron. Various sialylation levels of Tf are observed during physiological and pathological processes. We studied if the changes in iron stores as well as tobacco smoke may have an impact on foetal development and in consequence lead to intrauterine growth restriction (IUGR). In the third trimester of pregnancy, lower levels of 4-sialoTf isoform and higher levels of 5-sialoTf were observed in the serum of non-smoking women with IUGR in compa… Show more

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Cited by 3 publications
(4 citation statements)
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“…To determine long-term tobacco smoke exposure, Cd levels are a more suitable indicator [29]. Cd concentration in the blood of smoking women was 3.7-times higher than in the blood of non-smoking women, which is consistent with other research and points to tobacco smoke as a significant source of this heavy metal [3, 7, 30]. Cd concentrations in the blood correlated negatively with Zn levels (r = −0.823, p = 0.023) even if no differences between smoking and non-smoking women in the concentration of Zn were observed.…”
Section: Discussionsupporting
confidence: 58%
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“…To determine long-term tobacco smoke exposure, Cd levels are a more suitable indicator [29]. Cd concentration in the blood of smoking women was 3.7-times higher than in the blood of non-smoking women, which is consistent with other research and points to tobacco smoke as a significant source of this heavy metal [3, 7, 30]. Cd concentrations in the blood correlated negatively with Zn levels (r = −0.823, p = 0.023) even if no differences between smoking and non-smoking women in the concentration of Zn were observed.…”
Section: Discussionsupporting
confidence: 58%
“…Tobacco smoke influences the level of protein production, degradation and modification (e.g. sialylation) [7, 26]. Exposure to tobacco smoke additionally influences the inflammation what may be seen by raised levels of C-reactive protein and white blood cells [27].…”
Section: Discussionmentioning
confidence: 99%
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