Transfer hydrogenation of N-heteroarenes with 2-propanol and ethanol enabled by manganese catalysis

Abstract

A convenient manganese catalyzed transfer hydrogenation of N-heteroarenes by using alcohols as hydrogen source is presented. The ideal results are achieved by applying the 6-methyl substituted triazine based PiprN5Pipr manganese...

Manganese‐Catalyzed Transfer Hydrodebromination of Aryl Bromides with Ethanol

“…Although the mechanism for the present manganese catalyzed‐transfer hydro‐debromination has yet to be completely clear, a catalytic cycle is proposed based on our [19d] and others [18n,20] previous developments of the triazine‐based PNP manganese pincer catalysis (Scheme 4). The first step of the reaction would involve the formation of catalytically active species MnH 2K ( Mn‐A ) in the presence of KO t Bu and EtOH.…”

Sustainable Synthesis of α‐Hydroxycarboxylic Acids by Manganese Catalyzed Acceptorless Dehydrogenative Coupling of Ethylene Glycol and Primary Alcohols**

“…Various stoichiometric experiments were performed to probe the involvement of such manganese species (Section S9.1) [6] . The treatment of the precatalyst, Mn‐III , with KO t Bu results in the formation of the amido complex Mn‐IIIa ( 31 P NMR δ 126.5 ppm) [25b, 26] . The latter subsequently mediates the dehydrogenation of EG and primary alcohols.…”

Manganese-catalyzed hydrogenation, dehydrogenation, and hydroelementation reactions

“…Liu later performed an extensive study on the TH of heterocycles with Kempe's (PN 5 P)Mn( i )-complex Mn74 (Table 12, entry 2). 177 This catalyst was efficient in hydrogenating a wide range of substituted heterocycles in good to excellent yields. However, a higher catalyst loading, stoichiometric base, and higher temperature were necessary for high catalytic activities.…”