Dual
photoredox transition-metal catalysis has recently emerged
as a powerful tool for making synthetically challenging carbon–carbon
bonds under milder reaction conditions. Herein, we report on the visible-light-mediated
controlled generation of low-valent cobalt catalyst without the need
for a metallic reductant. It enabled C–C bond formation via
ene-yne coupling at room temperature. The generality of this dual
catalysis is demonstrated via the creation of sizable molecular diversity
with the accommodation of several functional groups.
Dearomative cycloaddition reaction serves as a blueprint for creating sp3-rich three-dimensional molecular topology from flat-aromatic compounds. However, severe reactivity and selectivity issues make this process arduous. Herein, we describe visible-light...
An enantioselective ortho-C(sp2)–H functionalization of ketones with 1,6-enynes is demonstrated via the photoredox/cobalt dual catalysis. The method exhibits high yields, functional group tolerance, and selectivity. Mechanistic studies suggested the operation...
Dearomative cycloaddition reaction serves as a blueprint for creating three-dimensional molecular topology from flat-aromatic compounds. However, severe reactivity and selectivity issues make this process challenging. Herein, we describe visible-light energy-transfer catalysis for the intermolecular dearomative [4+2] cycloaddition reaction of feed-stock naphthalene molecules with vinyl benzenes. Tolerating a wide range of functional groups, a variety of structurally diverse 2-acyl naphthalenes and styrenes could easily be converted to a diverse range of bicyclo[2.2.2]octa-2,5-diene scaffolds in high yields and selectivities. The late-stage modification of pharmaceutical agents further demonstrated the broad potentiality of this methodology. The efficacy of the introduced methods was further highlighted by the post-synthetic diversification of the products. Furthermore, photoluminescence, electrochemical, kinetic, and control experiments support the energy transfer catalysis
1,2,4-Triazoles are ubiquitous in pharmaceuticals, natural products, coordination chemistry, agrochemicals, and material science research. Herein we report a practical regioselective synthesis of 1,2,4-triazoles utilizing an amine oxidase-inspired catalysis. An o-quino-enzyme...
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