Transdermal iontophoretic drug delivery: advances and challenges

Ita, Kevin

doi:10.3109/1061186x.2015.1090442

Cited by 80 publications

(54 citation statements)

References 46 publications

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“…This occurs through processes called electromigration and electro-osmosis. 43 By combining these transdermal delivery techniques with SP, percutaneous transport may be complementarily augmented and maximized.…”

Section: Combining Transdermal Drug Delivery Techniquesmentioning

confidence: 99%

Recent advances in ultrasound-based transdermal drug delivery

Seah¹,

Teo²

2018

IJN

119

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The transdermal transport of pharmaceuticals possesses various advantageous properties over conventional drug administration techniques such as oral delivery and hypodermic injections. However, the stratum corneum persists as the main barrier, which impedes percutaneous transport. The ultrasound-based transdermal delivery of therapeutics is one of the techniques that are being investigated to overcome this obstacle. This review outlines the background information pertaining to sonophoresis and then discusses the individual sections of sonophoretic research. These areas include the sonophoretic application of various drugs, dual-frequency sonophoresis, synergistic combinations of transdermal drug delivery techniques, and the use of nanosized carriers in ultrasound-based transdermal delivery. The various challenges associated with sonophoretic drug delivery and trends of future research are also highlighted.

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Section: Combining Transdermal Drug Delivery Techniquesmentioning

confidence: 99%

Recent advances in ultrasound-based transdermal drug delivery

Seah¹,

Teo²

2018

IJN

119

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“…To address this challenge, researchers designed a variety of external stimuli methods to promote percutaneous drug absorption. These external triggers include iontophoresis, ultrasonic introduction, electroporation, and thermal perforation (Jabbari et al, 2015;Ita, 2016;Lopez-Ramirez et al, 2020). However, these methods can cause pain, and patients cannot administer the compounds by themselves.…”

Section: Introductionmentioning

confidence: 99%

Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

et al. 2020

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Sinomenine (SIN) is an anti-inflammatory alkaloid derived from Sinomenium acutum, and the products sinomenine hydrochloride (SH) tablets and injections have been marketed in China to treat rheumatoid arthritis (RA). Oral administration of SH has shortcomings of gastrointestinal irritation and low bioavailability. The injection may require professional training and higher cost. It is of interest to develop an alternative form that is easier to administer and avoids the first-pass metabolism. In this study, SHloaded dissolving microneedles (SH-MN) were fabricated using polyvinyl pyrrolidone and chondroitin sulfate with a casting method. In percutaneous permeation studies of In vitro, the cumulative permeation and permeation rate of SH-MN were 5.31 and 5.06 times higher than that of SH-gel (SH-G). In percutaneous pharmacokinetic studies, the values of the area under the curve after administration of SH-MN in the skin and blood were 1.43-and 1.63-fold higher than that of SH-G, respectively. In percutaneous absorption studies, SH-MN could absorb into tissue fluid; and dissolve after skin penetration. The drug was released along the channel and spread to surrounding skin tissue. After 4 h, the needle tip was almost completely dissolved, and the drug could penetrate to a depth of 200 lm under the skin. These results demonstrate that the SH-MN is an effective, safe, and simple strategy for transdermal SH delivery.

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“…The skin has a barrier function that protects the body from invasion of environmental substances and microorganisms; therefore, skin patches use various systems to enhance physical or chemical permeation to disrupt the barrier . Representative physical enhancers are iontophoresis , sonophoresis , electroporation , and microneedles . Chemical enhancers include some fatty acids , terpenes , esters , alcohols , peptides , and nanosized carriers such as lipid vesicles , and solid‐in‐oil (S/O) nanodispersions .…”

Section: Introductionmentioning

confidence: 99%

Solid‐in‐oil nanodispersions for transdermal drug delivery systems

Kitaoka

Wakabayashi

Kamiya

et al. 2016

Biotechnology Journal

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Transdermal administration of drugs has advantages over conventional oral administration or administration using injection equipment. The route of administration reduces the opportunity for drug evacuation before systemic circulation, and enables long‐lasting drug administration at a modest body concentration. In addition, the skin is an attractive route for vaccination, because there are many immune cells in the skin. Recently, solid‐in‐oil nanodisperison (S/O) technique has demonstrated to deliver cosmetic and pharmaceutical bioactives efficiently through the skin. S/O nanodispersions are nanosized drug carriers designed to overcome the skin barrier. This review discusses the rationale for preparation of efficient and stable S/O nanodispersions, as well as application examples in cosmetic and pharmaceutical materials including vaccines. Drug administration using a patch is user‐friendly, and may improve patient compliance. The technique is a potent transcutaneous immunization method without needles.

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Transdermal iontophoretic drug delivery: advances and challenges

Cited by 80 publications

References 46 publications

Recent advances in ultrasound-based transdermal drug delivery

Recent advances in ultrasound-based transdermal drug delivery

Polyvinylpyrrolidone microneedles for localized delivery of sinomenine hydrochloride: preparation, release behavior of in vitro & in vivo, and penetration mechanism

Solid‐in‐oil nanodispersions for transdermal drug delivery systems

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