Recent advances in ultrasound-based transdermal drug delivery

Seah, Brenden Cheong Qi; Teo, Boon Mian

doi:10.2147/ijn.s174759

Cited by 119 publications

(89 citation statements)

References 61 publications

(74 reference statements)

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“…Ultrasound (US)-mediated drug delivery systems are widely used in transdermal administration and central nervous system (CNS) disease treatment [46,47]. Moreover, a US-responsive delivery system was also introduced for anticancer therapy based on the advantages for deep penetration of acoustic wave.…”

Section: Ultrasound-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Ultrasound-responsive Nanogelsmentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…The shock waves contributing to the sonophoresis induced by US were hypothesized to structurally modify lipids of the stratum corneum to produce diffusion channels that allowed transdermal delivery [3][4][5] . The thermal effects of US also positively influence the drug diffusion coefficient and skin permeability coefficient, but might result in heating damage when administering thermally unstable transdermal drugs 6,7 .…”

mentioning

confidence: 99%

Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

Liao

Lin

Chuang

et al. 2020

Sci Rep

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Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both in vitro and in vivo models, while increasing the hair growth efficacy compared to single-frequency US sonication. the in vitro experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in in vitro Franz-diffusioncell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dualfrequency US-mediated MB cavitation can significantly increase both skin permeability and transdermal drug delivery. At the same US power density, hair growth was greater in the group with dual-frequency US plus MBs than in the group with single-frequency US plus MBs, without damaging the skin in mice.

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“…1c can be predicted to occur. In gelatin gel of a tissue mimicking material, bubbles or other defects exist in the gel as cavitation source during gelation 22 , thus the cavitation can be collapsed by sound pressure (vibration) of ultrasonic waves with a specific frequency [23][24][25][26][27] , resulting in a microjet due to bubble collapse at the needle portion. Thus, physical forces can be generated to increase the effectiveness of drug delivery in gelatin by causing permeabilization.…”

Section: Resultsmentioning

confidence: 99%

“…Conventional ultrasound has been used to enhance the absorption of drugs [14][15][16] , DNA/RNA 17,18 , genes 19,20 , and other compounds into cells 21 and tissues 22 . In the case of skin, when ultrasound energy meets the microbubbles existing at the skin interface, contraction, relaxation, vibration, and acoustic storms are generated [23][24][25][26][27] . Another phenomenon in ultrasound-mediated drug delivery is thermal effects, where energy absorption in the membrane due to viscous friction 23 , and collapses of bubbles in the liquid medium 12,13 .…”

mentioning

confidence: 99%

Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

Bok

Zhao

Jeon

et al. 2020

Sci Rep

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A multifunctional system comprised of hyaluronic acid microneedles was developed as an effective transdermal delivery platform for rapid local delivery. The microneedles can regulate the filling amount on the tip, by controlling the concentration of hyaluronic acid solution. Ultrasonication induces dissolution of the HA microneedles via vibration of acoustic pressure, and AC iontophoresis improves the electrostatic force-driven diffusion of HA ions and rhodamine B. The effect of ultrasound on rhodamine release was analyzed in vitro using a gelatin hydrogel. the frequency and voltage dependence of the Ac on the ion induction transfer was also evaluated experimentally. the results showed that the permeability of the material acts as a key material property. The delivery system based on ultrasonication and iontophoresis in microneedles increases permeation, thus resulting in shorter initial delivery time than that required by delivery systems based on passive or ultrasonication alone. This study highlights the significance of the combination between ultrasonic waves and iontophoresis for improving the efficiency of the microneedles, by shortening the reaction duration. We anticipate that this system can be extended to macromolecular and dependence delivery, based on drug response time.

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Recent advances in ultrasound-based transdermal drug delivery

Cited by 119 publications

References 61 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement

Ultrasonically and Iontophoretically Enhanced Drug-Delivery System Based on Dissolving Microneedle Patches

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